Assessment of key characteristics, methodology, and effect size measures used in meta‐analysis of human‐health‐related animal studies
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DOI: 10.1002/jrsm.1578
Abstract: Since the early 1990s the number of systematic reviews (SR) of animal studies has steadily increased. There is, however, little guidance on when and how to conduct a meta‐analysis of human‐health‐related animal studies. To gain… read more here.
Keywords: meta analysis; effect; effect size; meta ... See more keywords
Evidence for Rosa damascena efficacy in mental disorders in preclinical animal studies and clinical trials: A systematic review
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DOI: 10.1002/ptr.7496
Abstract: The aim of this systematic review was to identify animal preclinical studies and randomized controlled trials that looked at the effects of R. damascena in any form on different mental diseases. Up to September 2021,… read more here.
Keywords: rosa damascena; systematic review; mental disorders; animal studies ... See more keywords
Polydatin as a therapeutic alternative for central nervous system disorders: A systematic review of animal studies
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DOI: 10.1002/ptr.7497
Abstract: Polydatin, or piceid, is a natural stilbene found in grapes, peanuts, and wines. Polydatin presents pharmacological activities, including neuroprotective properties, exerting preventive and/or therapeutic effects in central nervous system (CNS) disorders. In the present study,… read more here.
Keywords: review; central nervous; systematic review; polydatin ... See more keywords
Fish collagen for skin wound healing: a systematic review in experimental animal studies.
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DOI: 10.1007/s00441-022-03625-w
Abstract: Collagen extracted from fishes has been appearing as an alternative for commercial porcine and bovine collagen and it has been considered interesting especially for membrane manufacturing in tissue engineering. Despite the positive in vitro effects… read more here.
Keywords: skin wound; wound healing; animal studies; collagen ... See more keywords
Animal studies are mandatory to investigate the poorly understood fate and effects of aluminum adjuvants administered to billions of humans and animals worldwide.
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DOI: 10.1016/j.autrev.2018.02.005
Abstract: In a recent paper Ameratunga; Languth, and Hawkes [1] raised “scientific and ethical concerns” pertaining to animalmodels of autoimmunity/autoinflammatory syndrome induced by adjuvants (ASIA) [1]. The authors have previously questioned the existence of ASIA using… read more here.
Keywords: animal studies; studies mandatory; effects aluminum; poorly understood ... See more keywords
The efficacy of probiotics as pharmacological treatment of cutaneous wounds: Meta‐analysis of animal studies
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DOI: 10.1016/j.ejps.2017.04.002
Abstract: Abstract The aim of the current meta‐analysis of animal studies was to evaluate the efficacy of probiotics as pharmacological treatment of cutaneous wounds. A systematic electronic literature search was conducted and in total six animal… read more here.
Keywords: treatment cutaneous; animal studies; analysis; treatment ... See more keywords
Intra-articular injection of mesenchymal stem cells in treating knee osteoarthritis: a systematic review of animal studies.
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DOI: 10.1016/j.joca.2018.01.010
Abstract: PURPOSE Mesenchymal stem cells (MSCs) injection has emerged as a novel treatment for knee osteoarthritis (KOA) but with inconsistent results in the experimental studies. Thus, the purpose of the present study is to evaluate the… read more here.
Keywords: animal studies; knee osteoarthritis; injection; intra articular ... See more keywords
Rapid maxillary expansion supplementary methods: A scoping review of animal studies.
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DOI: 10.1016/j.ortho.2022.100614
Abstract: INTRODUCTION Maxillary constriction is a relatively common condition. Various treatment modalities have been proposed for this condition such as rapid maxillary expansion (RME). Although RME can significantly expand the suture in a relatively short period… read more here.
Keywords: rapid maxillary; expansion supplementary; animal studies; supplementary methods ... See more keywords
Flavonoids and type 2 diabetes: Evidence of efficacy in clinical and animal studies and delivery strategies to enhance their therapeutic efficacy.
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DOI: 10.1016/j.phrs.2020.104629
Abstract: Diabetes mellitus type 2 (T2DM) is a metabolic disorder develops due to the overproduction of free radicals where oxidative stress could contribute it. Possible factors are defective insulin signals, glucose oxidation, and degradation of glycated… read more here.
Keywords: evidence efficacy; animal studies; delivery; efficacy ... See more keywords
Translation from animal studies of novel pharmacological therapies to clinical trials in cardiac arrest: A systematic review.
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DOI: 10.1016/j.resuscitation.2020.10.028
Abstract: BACKGROUND There is a lack of new promising therapies to improve the dismal outcomes from cardiac arrest. The objectives of this study were: (1) To identify novel pharmacological therapies investigated in experimental animal studies and… read more here.
Keywords: experimental animal; animal studies; novel pharmacological; cardiac arrest ... See more keywords
Computerized quantification of drugs synergism in animal studies or in clinical trials using only ten data points
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DOI: 10.1016/j.synres.2019.100049
Abstract: Abstract The median-effect equation (MEE) derived from the mass-action law (MAL) is the unified theory of dose-effect pharmacodynamics (PD) and biodynamics (BD). MEE enables the linearization of a dose-effect curve into a straight linedefined by… read more here.
Keywords: drug; animal studies; data points; effect ... See more keywords