PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202525076
Abstract: Lipid nanoparticles (LNPs) have emerged as transformative delivery vehicles for nucleic acid therapeutics, yet their development remains heavily dependent on extensive and iterative animal testing to assess their in vivo performance. Here, PREdicting LNP In… read more here.
Keywords: animal testing; reliance animal; lipid nanoparticles; design ... See more keywords
Advancing alternative methods to reduce animal testing.
Sign Up to like & getrecommendations! Published in 2024 at "Science"
DOI: 10.1126/science.adg6228
Abstract: Emerging approaches show promise for regulatory use. read more here.
Keywords: animal testing; alternative methods; reduce animal; advancing alternative ... See more keywords
Chemicals regulation and non-animal methods: displacing the gold standard
Sign Up to like & getrecommendations! Published in 2024 at "Wellcome Open Research"
DOI: 10.12688/wellcomeopenres.20581.2
Abstract: Regulating industrial chemicals in foodstuffs and consumer products is a major aspect of protecting populations against health risks. Non-animal testing methods are an essential part of the radical change to the framework for toxicity testing… read more here.
Keywords: non animal; animal testing; animal methods; chemicals regulation ... See more keywords
Bioethics: a look at animal testing in medicine and cosmetics in the UK
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Ethics and History of Medicine"
DOI: 10.18502/jmehm.v12i15.1875
Abstract: Using animals for cosmetics and medical tests has contributed towards a debate based on conflicting interests. Despite the efforts in justifying the value of animals in conducting analyses, this study seeks to elaborate whether or… read more here.
Keywords: medicine; medical cosmetics; bioethics look; animal testing ... See more keywords
Kidney Organoid and Microphysiological Kidney Chip Models to Accelerate Drug Development and Reduce Animal Testing
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.695920
Abstract: Kidneys are critical for the elimination of many drugs and metabolites via the urine, filtering waste and maintaining proper fluid and electrolyte balance. Emerging technologies incorporating engineered three-dimensional (3D) in vitro cell culture models, such… read more here.
Keywords: accelerate drug; drug development; animal testing; drug ... See more keywords
Innovative Human Three-Dimensional Tissue-Engineered Models as an Alternative to Animal Testing
Sign Up to like & getrecommendations! Published in 2020 at "Bioengineering"
DOI: 10.3390/bioengineering7030115
Abstract: Animal testing has long been used in science to study complex biological phenomena that cannot be investigated using two-dimensional cell cultures in plastic dishes. With time, it appeared that more differences could exist between animal… read more here.
Keywords: three dimensional; innovative human; animal testing; dimensional tissue ... See more keywords
Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22084216
Abstract: Millions of experimental animals are widely used in the assessment of toxicological or biological effects of manufactured nanomaterials in medical technology. However, the animal consciousness has increased and become an issue for debate in recent… read more here.
Keywords: current strategies; animal testing; assessment nanotoxicity; nanotoxicity alternatives ... See more keywords