Energy Metabolism and Mitochondrial Superoxide Anion Production in Pre-symptomatic Striatal Neurons Derived from Human-Induced Pluripotent Stem Cells Expressing Mutant Huntingtin
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Neurobiology"
DOI: 10.1007/s12035-019-01734-2
Abstract: In the present study, we investigated whether mutant huntingtin (mHTT) impairs mitochondrial functions in human striatal neurons derived from induced pluripotent stem cells (iPSCs). Striatal neurons and astrocytes derived from iPSCs from unaffected individuals (Ctrl)… read more here.
Keywords: huntingtin; anion production; striatal neurons; superoxide anion ... See more keywords
Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress
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DOI: 10.3390/ijms24043959
Abstract: Hypertension, a multifactorial chronic inflammatory condition, is an important risk factor for neurovascular and neurodegenerative diseases, including stroke and Alzheimer’s disease. These diseases have been associated with higher concentrations of circulating interleukin (IL)-17A. However, the… read more here.
Keywords: neurovascular coupling; anion production; hypertension; hypertension impaired ... See more keywords