Cellular Uptake of Levocetirizine by Organic Anion Transporter 4.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.03.026
Abstract: The pharmacokinetics of cetirizine, a nonsedating antihistamine, is profoundly affected by transporter-mediated membrane transport in the kidney. In this study, we aimed to investigate the transport mechanism of levocetirizine, the pharmacologically active enantiomer of cetirizine,… read more here.
Keywords: anion transporter; organic anion; levocetirizine; transporter ... See more keywords
Role of Hepatic Organic Anion Transporter 2 in the Pharmacokinetics of R- and S-Warfarin: In Vitro Studies and Mechanistic Evaluation.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.7b01108
Abstract: Interindividual variability in warfarin dose requirement demands personalized medicine approaches to balance its therapeutic benefits (anticoagulation) and bleeding risk. Cytochrome P450 2C9 ( CYP2C9) genotype-guided warfarin dosing is recommended in the clinic, given the more… read more here.
Keywords: warfarin; anion transporter; role hepatic; organic anion ... See more keywords
Utility of urinary organic anion transporter 5 as an early biomarker of obstructive nephropathy
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13360
Abstract: Ureteral obstruction is a relevant cause of kidney damage. The traditional parameters used in clinical practice for the detection of renal injury are insensitive and non‐specific for the diagnosis of obstructive renal disease. The organic… read more here.
Keywords: ureteral obstruction; obstructive nephropathy; biomarker obstructive; biomarker ... See more keywords
Bilirubin Reduces the Uptake of Estrogen Precursors and the Followed Synthesis of Estradiol in Human Placental Syncytiotrophoblasts via Inhibition and Downregulation of Organic Anion Transporter 4
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000685
Abstract: Estrogen biosynthesis in human placental trophoblasts requires the human organic anion transporter 4 (hOAT4)-mediated uptake of fetal derived precursors such as dehydroepiandrosterone-3-sulfate (DHEAS) and 16α-hydroxy-DHEA-S (16α-OH-DHEAS). Scant information is available concerning the contribution of fetal… read more here.
Keywords: estrogen; estradiol; bilirubin; synthesis ... See more keywords
Stereoselective Inhibition of Renal Basolateral Human Organic Anion Transporter 3 by Lansoprazole Enantiomers
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DOI: 10.1159/000485920
Abstract: Lansoprazole, a proton pump inhibitor, potently inhibits human organic anion transporter, hOAT3 (SLC22A8). Lansoprazole has an asymmetric atom in its structure and is clinically administered as a racemic mixture of (R)-and (S)-enantiomers. However, little is… read more here.
Keywords: anion transporter; human organic; lansoprazole enantiomers; organic anion ... See more keywords
Inhibition of proteasome, but not lysosome, upregulates organic anion transporter 3 in vitro and in vivo.
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DOI: 10.2139/ssrn.4252414
Abstract: Organic anion transporter 3 (OAT3), an indispensable basolateral membrane transporter predominantly distributed in the kidney proximal tubules, mediated the systemic clearance of substrates including clinical drugs, nutrients, endogenous and exogenous metabolites, toxins, and critically sustains… read more here.
Keywords: vitro vivo; inhibition; proteasome lysosome; transporter ... See more keywords