Renal organic anion transporters in drug–drug interactions and diseases
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2017.11.001
Abstract: ABSTRACT The kidney plays a vital role in maintaining systemic homeostasis. Active tubular secretion and reabsorption, which are mainly mediated by transporters, is an efficient mechanism for retaining glucose, amino acids, and other nutrients and… read more here.
Keywords: drug interactions; drug; anion transporters; organic anion ... See more keywords
Synthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers.
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DOI: 10.1021/acs.orglett.9b02823
Abstract: Cl--ion transporters (2a-2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl--ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the… read more here.
Keywords: transporters endoplasmic; synthetic anion; endoplasmic reticulum; reticulum stress ... See more keywords
Tetrapodal Anion Transporters †
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25215179
Abstract: Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via interacting with fatty acids present in the membrane.… read more here.
Keywords: anion; tetrapodal anion; anion transporters; transport ... See more keywords