Transcriptome and Gut Microbiota Profiling Analysis of ANIT-Induced Cholestasis and the Effects of Da-Huang-Xiao-Shi Decoction Intervention
Sign Up to like & getrecommendations! Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03242-22
Abstract: Cholestasis is a serious manifestation of liver diseases resulting in liver injury, fibrosis, and liver failure with limited therapies. To date, only ursodeoxycholic acid (UDCA) has been approved by the U.S. ABSTRACT Cholestasis is characterized… read more here.
Keywords: cholestasis; gut microbiota; anit induced; analysis ... See more keywords
SRT1720 Alleviates ANIT-Induced Cholestasis in a Mouse Model
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DOI: 10.3389/fphar.2017.00256
Abstract: Intrahepatic cholestasis is a kind of clinical syndrome along with hepatotoxicity which caused by intrahepatic and systemic accumulations of bile acid. There are several crucial generating factors of the pathogenesis of cholestasis, such as inflammation,… read more here.
Keywords: cholestasis; srt1720 alleviates; hepatotoxicity cholestasis; bile acid ... See more keywords
Quercetin 7-rhamnoside protects against alpha-naphthylisothiocyanate (ANIT)-induced in cholestatic hepatitis rats by improving biliary excretion and inhibiting inflammatory responses
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1116257
Abstract: Objective: To explore the pharmacological effects and molecular mechanism of quercetin 7-rhamnoside (Q7R) in the treatment of cholestatic hepatitis induced by alpha-naphthylisothiocyanate (ANIT). Methods: ANIT-induced cholestatic hepatitis rat model was used to investigate the hepatoprotective… read more here.
Keywords: induced cholestatic; anit induced; cholestatic hepatitis; hepatitis ... See more keywords
Ginsenosides Restore Lipid and Redox Homeostasis in Mice with Intrahepatic Cholestasis through SIRT1/AMPK Pathways
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DOI: 10.3390/nu14193938
Abstract: Intrahepatic cholestasis (IC) occurs when the liver and systemic circulation accumulate bile components, which can then lead to lipid metabolism disorders and oxidative damage. Ginsenosides (GS) are pharmacologically active plant products derived from ginseng that… read more here.
Keywords: cholestasis; anit induced; sirt1 ampk; intrahepatic cholestasis ... See more keywords