Conditional Knockout of Ankyrin-G In The Mouse Forebrain Results In Bipolar-Like Behavior
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2016.09.574
Abstract: Background To date, few animal models of bipolar disorder have been developed, and fewer still are based on genetic loci despite the fact that genome wide association studies (GWAS) have now identified a number of… read more here.
Keywords: social defeat; mice; ankyrin; conditional knockout ... See more keywords
Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2513363122
Abstract: The developing brain undergoes neuroplasticity driven by learning, experience, and memory formation. The axon initial segment (AIS) is a specialized membrane domain within the proximal axon that initiates action potential. Studies have demonstrated that the… read more here.
Keywords: mice; plasticity; excitability; ankyrin ... See more keywords
Ankyrin-B is required for the establishment and maintenance of lens cytoarchitecture, mechanics, and clarity.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of cell science"
DOI: 10.1242/jcs.262349
Abstract: The transparent ocular lens is essential for vision by focusing light onto the retina. Despite recognizing the importance of its unique cellular architecture and mechanical properties, the molecular mechanisms governing these attributes remain elusive. This… read more here.
Keywords: ankb; lens cytoarchitecture; mechanics; maintenance lens ... See more keywords
Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.828605
Abstract: Anaplasma phagocytophilum, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple ankyrin repeats (AR) is injected via type IV-secretion into the host neutrophil to gain… read more here.
Keywords: phagocytophilum; ankyrin; importin rangtp; anaplasma phagocytophilum ... See more keywords
Mechanisms and Alterations of Cardiac Ion Channels Leading to Disease: Role of Ankyrin-B in Cardiac Function
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10020211
Abstract: Ankyrin-B (encoded by ANK2), originally identified as a key cytoskeletal-associated protein in the brain, is highly expressed in the heart and plays critical roles in cardiac physiology and cell biology. In the heart, ankyrin-B plays… read more here.
Keywords: heart; ion channels; cardiac function; role ankyrin ... See more keywords
Spherocytosis-Related L1340P Mutation in Ankyrin Affects Its Interactions with Spectrin
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life13010151
Abstract: Previously, we reported a new missense mutation in the ANK1 gene correlated with the HS phenotype. This mutation, resulting in L1340P substitution (HGMD CM149731), likely leads to the changes in the conformation of the ankyrin… read more here.
Keywords: related l1340p; spherocytosis related; domain; ankyrin ... See more keywords
Sequence and Structure-Based Analyses of Human Ankyrin Repeats
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27020423
Abstract: Ankyrin is one of the most abundant protein repeat families found across all forms of life. It is found in a variety of multi-domain and single domain proteins in humans with diverse number of repeating… read more here.
Keywords: ankyrin proteins; human ankyrin; ankyrin; sequence structure ... See more keywords