Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains
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DOI: 10.1002/cbic.202200576
Abstract: Transient receptor potential (TRP) channels have important roles in environmental sensing in animals. Human TRP subfamily A member 1 (TRPA1) is responsible for sensing allyl isothiocyanate (AITC) and other electrophilic sensory irritants. TRP subfamily vanilloid… read more here.
Keywords: transient receptor; biochemical structural; receptor potential; hydroxylation ... See more keywords
Ankyrin repeat-containing N-Ank proteins shape cellular membranes
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DOI: 10.1038/s41556-019-0381-7
Abstract: Cells of multicellular organisms need to adopt specific morphologies. However, the molecular mechanisms bringing about membrane topology changes are far from understood—mainly because knowledge of membrane-shaping proteins that can promote local membrane curvatures is still… read more here.
Keywords: amphipathic helix; ank proteins; terminal amphipathic; membrane ... See more keywords
Multispecific Targeting with Synthetic Ankyrin Repeat Motif Chimeric Antigen Receptors
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DOI: 10.1158/1078-0432.ccr-19-1479
Abstract: Purpose: The outgrowth of antigen-negative variants is a significant challenge for adoptive therapy with T cells that target a single specificity. Chimeric antigen receptors (CAR) are typically designed with one or two scFvs that impart… read more here.
Keywords: ankyrin repeat; antigen; tumor; chimeric antigen ... See more keywords
A Plastid-Bound Ankyrin Repeat Protein Controls Gametophyte and Early Embryo Development in Arabidopsis thaliana
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DOI: 10.3389/fpls.2022.767339
Abstract: Proplastids are essential precursors for multi-fate plastid biogenesis, including chloroplast differentiation, a powerhouse for photosynthesis in plants. Arabidopsis ankyrin repeat protein (AKRP, AT5G66055) is a plastid-localized protein with a putative function in plastid differentiation and… read more here.
Keywords: plastid; embryo development; akrp; repeat protein ... See more keywords