Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes.
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DOI: 10.1021/acs.orglett.7b03721
Abstract: Indolizidine and quinolizidine derivatives are readily assembled from l-proline or (±)-pipecolic acid and β-ketoaldehydes via a decarboxylative annulation process. These reactions are promoted by acetic acid and involve azomethine ylides as reactive intermediates. read more here.
Keywords: annulation amino; annulation; amino acids; decarboxylative annulation ... See more keywords