An efficient [3+2] annulation for the asymmetric synthesis of densely-functionalized pyrrolidinones and γ-butenolides.
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DOI: 10.1039/d0cc05188h
Abstract: Disclosed here is a new [3+2] annulation of siloxy alkynes that provides robust access to highly enantioenriched, densely-substituted pyrrolidinones and γ-butenolides, whose direct synthesis remains challenging. This process also represents a rare asymmetric synthesis of… read more here.
Keywords: annulation asymmetric; efficient annulation; asymmetric synthesis; synthesis ... See more keywords