N-Heterocyclic Carbene-Catalyzed [3 + 2] Annulation of 3,3'-Bisoxindoles with α-Bromoenals: Enantioselective Construction of Contiguous Quaternary Stereocenters.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c02180
Abstract: An NHC-catalyzed enantio- and diastereoselective [3 + 2] annulation of α-bromoenals with bisoxindoles is developed, affording efficient access to various spirocyclic bisoxindole alkaloids. This protocol tolerates a broad substrates scope, with various spirocyclic bisoxindoles obtained… read more here.
Keywords: quaternary stereocenters; catalyzed annulation; annulation; annulation bisoxindoles ... See more keywords