NHC-Catalyzed Enantioselective [3 + 3] Annulation to Construct 5,6-Dihydropyrimidin-4-ones.
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DOI: 10.1021/acs.orglett.0c02832
Abstract: The unprecedented enantioselective NHC-catalyzed [3 + 3] annulation of α-bromoenals with amidines via a dual C-N bond formation is described. The protocol allows a rapid preparation of 5,6-dihydropyrimidinones in acceptable yields with good enantioselectivities. read more here.
Keywords: annulation; construct dihydropyrimidin; nhc catalyzed; catalyzed enantioselective ... See more keywords
Phosphine-Mediated Sequential [2+4]/[2+3] Annulation to Construct Pyrroloquinolines.
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DOI: 10.1021/acs.orglett.1c04388
Abstract: A domino [2+4]/[2+3] sequential annulation reaction of MBH carbonates with N-unprotected indoles has been developed to provide various pyrroloquinoline derivatives in ≤94% yield and 20:1 dr. The reaction could be either mediated by stoichiometric PCy3… read more here.
Keywords: annulation construct; sequential annulation; mediated sequential; annulation ... See more keywords