Asymmetric [3 + 3] Annulation of Copper-Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3- c]pyrazoles.
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DOI: 10.1021/acs.orglett.8b02214
Abstract: The copper-catalyzed asymmetric [3 + 3] annulation of ethynyl benzoxazinanones with pyrazolones has been achieved, providing simple access to 1,4-dihydropyrano[2,3- c]pyrazole derivatives in moderate to excellent yields with excellent enantioselectivities (up to 99% ee). Compared… read more here.
Keywords: dihydropyrano; annulation; copper allenylidenes; annulation copper ... See more keywords