Carbene-Catalyzed Atroposelective Annulation and Desymmetrization of Urazoles.
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DOI: 10.1021/acs.orglett.1c01191
Abstract: An NHC-catalyzed atroposelective reaction between ynals and urazoles is disclosed. The reaction establishes a chiral C-N axis via an atroposelective [3 + 2] annulation/desymmetrization process. Our reaction allows efficient access to axially chiral and heteroatom-rich… read more here.
Keywords: annulation desymmetrization; carbene catalyzed; atroposelective annulation; catalyzed atroposelective ... See more keywords