Annulation of pyrrole ring in 4-acylpyridine-3,5-dicarbonitriles in the presence of ammonia
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DOI: 10.1007/s10593-019-02434-4
Abstract: 4-Acyl-2-amino-6-chloropyridine-3,5-dicarbonitriles underwent heterocyclization in the presence of ammonia in aqueous dioxane medium, involving the ortho-ketonitrile fragment while preserving the halogen atom. The pyrrole ring annulation process proceeded regioselectively with the formation of a single positional… read more here.
Keywords: pyrrole ring; annulation pyrrole; acylpyridine dicarbonitriles; ring acylpyridine ... See more keywords
Annulation of 1H-pyrrole-2,3-diones by thioacetamide: an approach to 5-azaisatins
Sign Up to like & getrecommendations! Published in 2019 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.15.32
Abstract: A novel approach to 1H-pyrrolo[3,2-c]pyridine-2,3-diones (5-azaisatins) has been developed via an unprecedented annulation of pyrrolo[2,1-c][1,4]benzoxazine-1,2,4-triones by thioacetamide. A new way of C–H functionalization of thioacetamide has been discovered. The reaction proceeds under green catalyst-free conditions. read more here.
Keywords: approach azaisatins; annulation pyrrole; diones thioacetamide; approach ... See more keywords