Copper-catalysed asymmetric annulation of yne-allylic esters with amines to access axially chiral arylpyrroles
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DOI: 10.1038/s41467-024-50896-8
Abstract: The construction of atropisomers with 1,2-diaxes, while maintaining high enantiocontrol, presents a significant challenge due to the dynamic nature of steric hindrance at ortho-aryl substituents. Although various catalytic asymmetric methods have been developed for accessing… read more here.
Keywords: axially chiral; allylic esters; chiral arylpyrroles; copper catalysed ... See more keywords