Phase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles.
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DOI: 10.1021/acs.orglett.1c04174
Abstract: A general phase-transfer-catalyzed asymmetric (n+1) (n = 4 or 5) annulation reaction, featuring the direct coupling of simple oxindoles with alkyl dihalides that are allylic/benzylic and non-allylic/benzylic, has been developed to provide previously inaccessible cyclopentane-… read more here.
Keywords: transfer catalyzed; phase transfer; alkyl dihalides; catalyzed asymmetric ... See more keywords