Gold-Catalyzed Bicyclic Annulations of N-(o-Alkynylphenyl)imines with α-Diazo Esters to Form 5,6-Dihydroindolo[2,1-a]isoquinolines.
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DOI: 10.1021/acs.orglett.2c00450
Abstract: One-pot synthesis of 5,6-dihydroindolo[2,1-a]isoquinolines from gold-catalyzed annulations between N-(o-alkynylphenyl)imines and α-diazo esters is described. This cascade reaction involves an initial attack of the diazo ester at the imine to form cis-aziridine, followed by stereoselective [3… read more here.
Keywords: dihydroindolo isoquinolines; imines diazo; alkynylphenyl imines; annulations alkynylphenyl ... See more keywords