Umpolung (4 + 1) Annulations of Bifunctional Hydroxylamines: A Modular Approach to Pyrrolidines.
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DOI: 10.1021/acs.orglett.5c01285
Abstract: Herein we describe a modular and umpolung (4 + 1) cyclization strategy for synthesizing functionalized 2,2-disubstituted pyrrolidines decorated with versatile alkene, alkyne, and carbonyl groups under mild basic conditions. The new approach employs readily accessible… read more here.
Keywords: umpolung annulations; bifunctional hydroxylamines; annulations bifunctional; modular approach ... See more keywords