Hyaluronic Acid Microgels Modulate Inflammation and Key Matrix Molecules toward a Regenerative Signature in the Injured Annulus Fibrosus
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Biosystems"
DOI: 10.1002/adbi.201700077
Abstract: Low back pain results from disc degeneration, which is a chronic inflammatory disease characterized by an imbalance between anabolic and catabolic factors. Today, regenerative medicine is focused on identifying inflammatory markers to target disc disease.… read more here.
Keywords: anti inflammatory; matrix; annulus fibrosus; hyaluronic acid ... See more keywords
Insights into the role of water concentrations on nanomechanical behavior of type I collagen-hyaluronan interfaces in annulus fibrosus: A molecular dynamics investigation.
Sign Up to like & getrecommendations! Published in 2023 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3713
Abstract: Multi-faceted deformation capabilities of Annulus Fibrosus (AF) results from an intricate mechanical design by nature. Wherein, organization and interactions between the constituents, collagen type I (CI), collagen type II (C2), hyaluronan, aggrecan, and water are… read more here.
Keywords: type collagen; water; molecular dynamics; water concentrations ... See more keywords
Prediction of clinically relevant initiation and progression of tears within annulus fibrosus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Orthopaedic Research"
DOI: 10.1002/jor.23346
Abstract: Internal disc disruption and annular tears are some of the causes of back and leg pain. It is difficult to observe location of internal damage and its distribution and propagation in cadaveric experiments or via… read more here.
Keywords: initiation; annulus fibrosus; loading conditions; damage ... See more keywords
Differentiation of adipose stem cells seeded towards annulus fibrosus cells on a designed poly(trimethylene carbonate) scaffold prepared by stereolithography
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2170
Abstract: Cell‐based therapies could potentially restore the biomechanical function and enhance the self‐repair capacity of annulus fibrosus (AF) tissue. However, choosing a suitable cell source and scaffold design are still key challenges. In this study, we… read more here.
Keywords: adipose stem; annulus fibrosus; poly trimethylene; differentiation ... See more keywords
Pressure-induced end-plate fracture in the porcine spine: Is the annulus fibrosus susceptible to damage?
Sign Up to like & getrecommendations! Published in 2017 at "European Spine Journal"
DOI: 10.1007/s00586-017-5428-5
Abstract: AbstractPurposeTo determine if the mechanical properties of the annulus fibrosus (AF) are altered following end-plate fracture. Vertebral fractures, particularly those in the growth plate, are relatively common among adolescents. What is unclear is whether or… read more here.
Keywords: plate fracture; annulus fibrosus; plate; damage ... See more keywords
A growth-based model for the prediction of fiber angle distribution in the intervertebral disc annulus fibrosus
Sign Up to like & getrecommendations! Published in 2019 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-019-01150-4
Abstract: There is a growing interest in the development of patient-specific finite element models of the human lumbar spine for both the assessment of injury risk and the development of treatment strategies. A current challenge in… read more here.
Keywords: fiber angle; annulus fibrosus; model; geometry ... See more keywords
Angle-ply biomaterial scaffold for annulus fibrosus repair replicates native tissue mechanical properties, restores spinal kinematics, and supports cell viability.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.06.006
Abstract: Annulus fibrosus (AF) damage commonly occurs due to intervertebral disc (IVD) degeneration/herniation. The dynamic mechanical role of the AF is essential for proper IVD function and thus it is imperative that biomaterials developed to repair… read more here.
Keywords: angle ply; annulus fibrosus; kinematics; native tissue ... See more keywords
Ultrastructural organization of elastic fibres in the partition boundaries of the annulus fibrosus within the intervertebral disc.
Sign Up to like & getrecommendations! Published in 2018 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.12.017
Abstract: The relationship between elastic fibre disorders and disc degeneration, aging and progression of spine deformity have been discussed in a small number of studies. However, the clinical relevance of elastic fibres in the annulus fibrosus… read more here.
Keywords: ultrastructural organization; network; fibre; annulus fibrosus ... See more keywords
Rapid increase in intradiscal pressure in porcine cervical spine units negatively impacts annulus fibrosus strength.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of biomechanics"
DOI: 10.1016/j.jbiomech.2020.109888
Abstract: Vertebral endplate fracture is generally accepted to occur as a result of excessive, typically rapid, pressure developed within the intervertebral disc. Clinical evidence of disc disorders later in life following endplate fracture suggests that the… read more here.
Keywords: strength; fracture; annulus fibrosus; endplate fracture ... See more keywords
Multi-laminate annulus fibrosus repair scaffold with an interlamellar matrix enhances impact resistance, prevents herniation and assists in restoring spinal kinematics.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the mechanical behavior of biomedical materials"
DOI: 10.1016/j.jmbbm.2019.03.030
Abstract: Focal defects in the annulus fibrosus (AF) of the intervertebral disc (IVD) arising from herniation have detrimental impacts on the IVD's mechanical function. Thus, biomimetic-based repair strategies must restore the mechanical integrity of the AF… read more here.
Keywords: impact; annulus fibrosus; kinematics; herniation ... See more keywords
Targeting Endogenous Reactive Oxygen Species Removal and Regulating Regenerative Microenvironment at Annulus Fibrosus Defects Promote Tissue Repair.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c00093
Abstract: The excessive reactive oxygen species (ROS) level, inflammation, and weak tissue regeneration ability after annulus fibrosus (AF) injury constitute an unfavorable microenvironment for AF repair. AF integrity is crucial for preventing disc herniation after discectomy;… read more here.
Keywords: reactive oxygen; microenvironment; targeting endogenous; oxygen species ... See more keywords