The Mechanistic Role of the Calcium-Activated Chloride Channel ANO1 in Tumor Growth and Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2016_201
Abstract: Multiple studies have described the high expression and amplification of Anoctamin 1 (ANO1) in various cancers, including, but not limited to breast cancer, head and neck cancer, gastrointestinal stromal tumors and glioblastoma. ANO1 has been… read more here.
Keywords: chloride channel; calcium activated; cancer; ano1 ... See more keywords
Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-1756-9_3
Abstract: Primary sensory neurons detect potentially dangerous environmental situations via many "sensor" proteins located on the plasma membrane. Although receptor-type cation channels are thought to be the major sensors in sensory neurons, anion channels are also… read more here.
Keywords: pain; sensory neurons; ano1; trpv1 ano1 ... See more keywords
Transcriptional activation of ANO1 promotes gastric cancer progression.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.03.001
Abstract: The prognosis of gastric cancer (GC) remains poor due to local invasion and distal metastasis. The GC-related molecular mechanisms underlying invasion and metastasis are not well understood. In this study, we investigated the functional role… read more here.
Keywords: gastric cancer; metastasis; ano1; progression ... See more keywords
Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2+
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DOI: 10.1038/s41467-025-58682-w
Abstract: ANO1 plays a crucial role in determining numerous physiological functions, including epithelial secretion, yet its regulatory mechanisms remain incompletely understood. Here, we describe a fundamental dynamic regulation of ANO1 surface expression and Ca2+-dependent gating via… read more here.
Keywords: camp pka; pka; ano1; ca2 ... See more keywords
Detection of ANO1 mRNA in PBMCs is a promising method for GISTs diagnosis
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DOI: 10.1038/s41598-019-45941-2
Abstract: ANO1 is a calcium-activated chloride channel protein that has been used to diagnose GISTs after tissue biopsy. Recently, ANO1 mRNA amplification in the blood has received considerable attention as a useful method for the diagnosis… read more here.
Keywords: pbmcs promising; ano1 mrna; mrna pbmcs; ano1 ... See more keywords
Ano1 is a Prognostic Biomarker That is Correlated with Immune Infiltration in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s348296
Abstract: Background Anoctamin 1 (ANO1) has been observed to be overexpressed in gastrointestinal and pulmonary epithelial cells, as well as in a number of cancers. Although Ano1 is involved in the prognosis of colorectal cancer (CRC),… read more here.
Keywords: ano1; crc; analysis; colorectal cancer ... See more keywords