Flavoxanthin Binds to AGR2 to Mediate Fatty Acid Oxidation and Reinforce Anoikis in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Drug Development Research"
DOI: 10.1002/ddr.70129
Abstract: Traditional Chinese medicine (TCM) can not only alleviate symptoms in cancer patients and improve their life quality but also serve as an adjuvant therapy to reduce the toxic side effects of chemotherapy and radiotherapy, making… read more here.
Keywords: acid oxidation; agr2; luad; medicine ... See more keywords
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53‐AMPK axis
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.04.013
Abstract: ABSTRACT Anoikis‐resistance is an essential feature of cancer cells to obtain successful metastasis, whereas the molecular mechanism involved in this process of hepatocellular carcinoma (HCC) cells is not fully understood. Here we demonstrated that tripartite… read more here.
Keywords: trim31; hcc cells; anoikis; resistance ... See more keywords
Gene expression profile of anoikis reveals new subtypes of liver cancer and discovery of therapeutic targets and biomarkers
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DOI: 10.1038/s41598-025-96488-4
Abstract: Hepatocellular carcinoma and cholangiocarcinoma, the two predominant histological subtypes of primary liver cancer, are characterized by a high global incidence and poor prognosis. Moreover, the therapeutic options are still limited, with surgical intervention being the… read more here.
Keywords: therapeutic targets; cancer; gene expression; liver cancer ... See more keywords
Proteolytic Release of the p75NTR Intracellular Domain by ADAM10 Promotes Metastasis and Resistance to Anoikis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-2789
Abstract: Resistance to anoikis allows cancer cells to survive during systemic circulation; however, the mechanism underlying anoikis resistance remains unclear. Here we show that A disintegrin and metalloprotease 10 (ADAM10)-mediated cleavage of p75 neurotrophin receptor (p75NTR)… read more here.
Keywords: p75ntr; anoikis; p75ntr icd; resistance ... See more keywords
Clinical value of anoikis-related genes and molecular subtypes identification in bladder urothelial carcinoma and in vitro validation
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1122570
Abstract: Background Anoikis is a programmed cell death process that was proven to be associated with cancer. Uroepithelial carcinoma of the bladder (BLCA) is a malignant disease of the urinary tract and has a strong metastatic… read more here.
Keywords: value anoikis; associated genes; risk; carcinoma ... See more keywords
Comprehensive analysis of anoikis-related gene signature in ulcerative colitis using machine learning algorithms
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2025.1498864
Abstract: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with an idiopathic origin, characterized by persistent mucosal inflammation. Anoikis is a programmed cell death mechanism activated during carcinogenesis to eliminate undetected isolated cells from the… read more here.
Keywords: immune cells; analysis; machine; ulcerative colitis ... See more keywords
The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22020627
Abstract: Cancer is a global health concern, and the prognosis of patients with cancer is associated with metastasis. Multistep processes are involved in cancer metastasis. Accumulating evidence has shown that cancer cells acquire the capacity of… read more here.
Keywords: anchorage independent; anoikis; noncoding rnas; cancer ... See more keywords
Mammalian Ste20-like kinase 1 inhibition as a cellular mediator of anoikis in mouse bone marrow mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2023 at "World Journal of Stem Cells"
DOI: 10.4252/wjsc.v15.i3.90
Abstract: BACKGROUND The low survival rate of mesenchymal stem cells (MSCs) caused by anoikis, a form of apoptosis, limits the therapeutic efficacy of MSCs. As a proapoptotic molecule, mammalian Ste20-like kinase 1 (Mst1) can increase the… read more here.
Keywords: inhibition; mst1 inhibition; expression; anoikis ... See more keywords