Fc-Mediated Anomalous Biodistribution of Therapeutic Antibodies in Immunodeficient Mouse Models.
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DOI: 10.1158/0008-5472.can-17-1958
Abstract: A critical benchmark in the development of antibody-based therapeutics is demonstration of efficacy in preclinical mouse models of human disease, many of which rely on immunodeficient mice. However, relatively little is known about how the… read more here.
Keywords: therapeutic antibodies; mouse models; biodistribution; anomalous biodistribution ... See more keywords