Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109997
Abstract: The anorexigenic effect of serotonergic compounds has largely been attributed to activation of serotonin 2C receptors (Htr2cs). Using mouse genetic models in which Htr2c can be selectively deleted or restored (in Htr2c-null mice), we investigate… read more here.
Keywords: nucleus hypothalamus; paraventricular nucleus; serotonin; effect ... See more keywords
A Short-Length Peptide YY Analogue with Anorectic Effect in Mice
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DOI: 10.1021/acsomega.7b00258
Abstract: Peripheral administration of PYY3–36, a fragment of peptide YY (PYY), has been reported to reduce food intake by activating the neuropeptide Y2 receptor (Y2R). An N-terminally truncated PYY analogue, benzoyl-[Ala26,Ile28,31]PYY(25–36) (1), showed a relatively potent… read more here.
Keywords: short length; activity; anorectic effect; mice ... See more keywords