SRSF10 inhibits the polymerase activity and replication of avian influenza virus by regulating the alternative splicing of chicken ANP32A.
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.198063
Abstract: Compared with mammalian ANP32A, most avian-coded ANP32A contains a 33 amino acids insertion (ch-ANP32A-33) or a 29 amino acids insertion (ch-ANP32A-29), which can rescue the mammalian-restricted avian influenza virus polymerase activity, with ch-ANP32A-33 exhibiting a… read more here.
Keywords: anp32a; avian influenza; polymerase; influenza virus ... See more keywords
Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A
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DOI: 10.1038/s41467-020-17407-x
Abstract: Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. Adaptive mutants are localised on the C-terminal (627-NLS) domains of the PB2 subunit. In particular, mutation of PB2 residue 627 from… read more here.
Keywords: host adaptation; pb2; polymerase; anp32a ... See more keywords
ANP32A promotes the proliferation, migration and invasion of hepatocellular carcinoma by modulating the HMGA1/STAT3 pathway.
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DOI: 10.1093/carcin/bgaa138
Abstract: ANP32A (acidic leucine-rich nuclear phosphoprotein-32A) has been reported to play an essential role in the development and progression of various human cancers. However, its expression pattern and possible mechanism in human hepatocellular carcinoma (HCC) remain… read more here.
Keywords: anp32a; migration invasion; hcc; proliferation migration ... See more keywords
ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone
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DOI: 10.1126/scitranslmed.aar8426
Abstract: ANP32A is a transcriptional regulator of ATM and provides protection against oxidative stress to prevent joint, brain, and bone disease. Oxidative stress and osteoarthritis Osteoarthritis is a common degenerative joint disorder that affects cartilage and… read more here.
Keywords: anp32a; brain bone; stress; cartilage ... See more keywords
ANP32A modulates cell growth by regulating p38 and Akt activity in colorectal cancer.
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DOI: 10.3892/or.2017.5845
Abstract: Acidic leucine-rich nuclear phosphoprotein-32A (ANP32A) possesses multiple biochemical activities, has been found to be decreased or absent in malignant tumors. However, new findings have shown that it is expressed in greater amounts in advanced cancers… read more here.
Keywords: anp32a; akt; colorectal cancer; expression ... See more keywords