Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745
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DOI: 10.1080/14786419.2016.1263854
Abstract: Abstract The actinomycete DEM20745, collected from non-rhizosphere soil adjacent to Paraserianthes falactaria trees (Cangkringan, Indonesia), is an efficient producer of the anticancer ansamycin polyketide 17-O-demethyl-geldanamycin (17-O-DMG), a biosynthetic precursor of the Hsp90 inhibitor geldanamycin (GDM).… read more here.
Keywords: production demethyl; ansamycin polyketide; geldanamycin; demethyl geldanamycin ... See more keywords