Discovery of Nonracemic Amisulpride to Maximize Benefit/Risk of 5‐HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2282
Abstract: In contrast to the dose‐occupancy relationship in the treatment of schizophrenia, the minimal effective level of dopamine receptor 2 (D2R) blockade for antipsychotics in the treatment of bipolar depression is unknown. Lower doses aimed at… read more here.
Keywords: d2r blockade; d2r; benefit; treatment ... See more keywords
Contingency rules for pathogen competition and antagonism in a genetically based, plant defense hierarchy
Sign Up to like & getrecommendations! Published in 2019 at "Ecology and Evolution"
DOI: 10.1002/ece3.5253
Abstract: Abstract Plant defense against pathogens includes a range of mechanisms, including, but not limited to, genetic resistance, pathogen‐antagonizing endophytes, and pathogen competitors. The relative importance of each mechanism can be expressed in a hierarchical view… read more here.
Keywords: pathogen antagonism; pathogen; plant; defense ... See more keywords
Reverse Erythroblastosis Virus α Antagonism Promotes Homocysteine Catabolism and Ammonia Clearance
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30675
Abstract: Metabolic homeostasis of amino acids is essential for human health. Here, we aimed to investigate a potential role for the clock component reverse erythroblastosis virus α (Rev‐erbα) in circadian regulation of amino acid metabolism. RNA‐seq… read more here.
Keywords: rev erb; ammonia clearance; erb; antagonism ... See more keywords
Effects of Mn2+ on Cd Accumulation and Ionome in Rice and Spinach.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of environmental quality"
DOI: 10.1002/jeq2.20358
Abstract: Health risk caused by Cd containing food is concerned worldwide. Interaction between Mn and Cd has been widely studied in normal hydroponic solution with high ion activities, e.g., the study on sharing of transporter Natural… read more here.
Keywords: rice spinach; rice; mn2; spinach ... See more keywords
Three New Soil-inhabiting Species of Trichoderma in the Stromaticum Clade with Test of Their Antagonism to Pathogens
Sign Up to like & getrecommendations! Published in 2017 at "Current Microbiology"
DOI: 10.1007/s00284-017-1282-2
Abstract: Trichoderma is a dominant component of the soil mycoflora. During the field investigations of northern, central, and southwestern China, three new species in the Stromaticum clade were encountered from soil, and named as T. hebeiense,… read more here.
Keywords: new species; three new; new soil; stromaticum clade ... See more keywords
Paradoxical elevation of plasma dabigatran after reversal with idarucizumab in stroke thrombolysis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neurology"
DOI: 10.1007/s00415-018-9011-8
Abstract: Idarucizumab can completely reverse the biological activity of dabigatran within a few minutes [1]. Several reports have documented thrombolytic therapy following antagonism of dabigatran with idarucizumab, and various arrangements have been made in different countries… read more here.
Keywords: plasma dabigatran; dabigatran; concentration; antagonism ... See more keywords
Role of cholinergic receptors in memory retrieval depends on gender and age of memory
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.05.017
Abstract: HighlightsAcute and sub‐chronic muscarinic antagonism impairs spatial memory recall.Acute muscarinic antagonism impairs fear memory recall in males and females.Remote fear recall in females is independent of muscarinic receptors.Sub‐chronic nicotinic antagonism impairs fear recall in females… read more here.
Keywords: memory retrieval; sub chronic; cholinergic receptors; antagonism ... See more keywords
EphA2 antagonism alleviates LPS-induced acute lung injury via Nrf2/HO-1, TLR4/MyD88 and RhoA/ROCK pathways.
Sign Up to like & getrecommendations! Published in 2019 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2019.04.008
Abstract: Eph receptor tyrosine kinases have a wide range of biological functions and have gradually been recognized increasingly as key regulators of inflammation and injury diseases. Although previous studies suggested that EphA2 receptor may be involved… read more here.
Keywords: tlr4 myd88; lps induced; epha2 antagonism; rhoa rock ... See more keywords
Pathological personality traits and immoral tendencies
Sign Up to like & getrecommendations! Published in 2019 at "Personality and Individual Differences"
DOI: 10.1016/j.paid.2018.02.043
Abstract: Abstract The overarching goal of the present studies was to explore the connections between pathological personality traits and an array of immoral tendencies. Across three studies, we predicted that individuals with certain pathological personality traits… read more here.
Keywords: personality traits; traits immoral; antagonism; pathological personality ... See more keywords
Histamine H4 receptor antagonism prevents the progression of diabetic nephropathy in male DBA2/J mice
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacological Research"
DOI: 10.1016/j.phrs.2018.01.002
Abstract: &NA; Due to the incidence of diabetes and the related morbidity of diabetic nephropathy, identification of new therapeutic strategies represents a priority. In the last few decades new and growing evidence on the possible role… read more here.
Keywords: histamine; diabetic nephropathy; progression; antagonism ... See more keywords
Contact-Dependent Interbacterial Antagonism Mediated by Protein Secretion Machines.
Sign Up to like & getrecommendations! Published in 2020 at "Trends in microbiology"
DOI: 10.1016/j.tim.2020.01.003
Abstract: To establish and maintain an ecological niche, bacteria employ a wide range of pathways to inhibit the growth of their microbial competitors. Some of these pathways, such as those that produce antibiotics or bacteriocins, exert… read more here.
Keywords: contact dependent; protein secretion; interbacterial antagonism; dependent interbacterial ... See more keywords