Adenosine A2a Receptor Antagonism Restores Additive Cytotoxicity by Cytotoxic T Cells in Metabolically Perturbed Tumors
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DOI: 10.1158/2326-6066.cir-22-0113
Abstract: Extracellular adenosine in the tumor microenvironment can impair antitumor immunity by suppressing CTL responses. Inhibition of adenosine signaling stabilizes CTL–target cell conjugation and increases sublethal hit frequency, and thereby restores CTL-mediated cytotoxicity against antigenic melanoma… read more here.
Keywords: cytotoxicity; adenosine a2a; antagonism restores; restores additive ... See more keywords