Metabolism Balance Regulation via Antagonist‐Functionalized Injectable Microsphere for Nucleus Pulposus Regeneration
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202006333
Abstract: Antagonist therapy represents a potential treatment for extracellular matrix (ECM) metabolic imbalance via the specific binding of inflammatory factors resulting from inflammation. However, the short half‐life of antagonist bioactivity creates challenges for their clinical application.… read more here.
Keywords: antagonist functionalized; functionalized injectable; antagonist; balance ... See more keywords
Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5130-2
Abstract: RationaleSocial withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e., there is a significant unmet medical need in the treatment of… read more here.
Keywords: interaction; interaction deficits; antagonist; receptor ... See more keywords
The Effects of Neurokinin-1 Receptor Antagonist in an Experimental Autoimmune Cystitis Model Resembling Bladder Pain Syndrome/Interstitial Cystitis
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DOI: 10.1007/s10753-018-0888-2
Abstract: To identify the effects of the neurokinin-1 receptor (NK1R) antagonist aprepitant in treating pelvic pain, micturition symptoms, and bladder inflammation in mice with experimental autoimmune cystitis (EAC) similar to bladder pain syndrome/interstitial cystitis (BPS/IC). Female… read more here.
Keywords: cystitis; bladder; eac; mice ... See more keywords
The effects of a growth hormone-releasing hormone antagonist and a gastrin-releasing peptide antagonist on intimal hyperplasia of the carotid artery after balloon injury in a diabetic rat model
Sign Up to like & getrecommendations! Published in 2017 at "Artery Research"
DOI: 10.1016/j.artres.2017.06.006
Abstract: Abstract Introduction Arterial restenosis after angioplasty/stenting has hindered coronary artery disease treatment, especially in diabetics. We theorized that gastrin-releasing peptide (GRP) antagonists and growth hormone-releasing hormone (GHRH) antagonists might decrease neointimal hyperplasia and restenosis in… read more here.
Keywords: artery; releasing peptide; antagonist; growth ... See more keywords
Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.03.037
Abstract: ABSTRACT Stress‐induced altered visceral sensation and impaired gut barrier play an important role in the pathophysiology of irritable bowel syndrome (IBS). These responses were demonstrated to be peripheral corticotropin‐releasing factor (CRF) dependent and also mediated… read more here.
Keywords: gut barrier; stress induced; model; antagonist ... See more keywords
The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.06.014
Abstract: The acetylcholine muscarinic M1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M1… read more here.
Keywords: muscarinic receptor; medication; antagonist; receptor ... See more keywords
NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular immunology"
DOI: 10.1016/j.molimm.2017.07.012
Abstract: NPS 2143, a novel and selective antagonist of calcium-sensing receptor (CaSR) has been reported to possess anti-inflammatory activity. In the present study, we examined the protective effect of NPS 2143 on lipopolysaccharide (LPS)-induced acute lung… read more here.
Keywords: nps; nps 2143; antagonist; sensing receptor ... See more keywords
NMDA receptor antagonist rodent models for cognition in schizophrenia and identification of novel drug treatments, an update
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.11.045
Abstract: &NA; Negative and cognitive deficit symptoms in schizophrenia remain an unmet clinical need. Improved understanding of the neuro‐ and psychopathology of cognitive dysfunction in the illness is urgently required to enhance the development of new… read more here.
Keywords: cognition schizophrenia; rodent; effects nmdar; antagonist ... See more keywords
The adenosine A2A receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2022.108981
Abstract: Blockade of adenosine A2A receptors (A2ARs) protects against neuronal damage caused by various brain insults including mitochondrial toxicity, but the precise neuroprotective mechanisms are unclear. Here, we studied the effects of the A2AR antagonist KW6002… read more here.
Keywords: retinal injury; injury; network; antagonist ... See more keywords
The antagonistic activity of H1 receptor antagonists as medicinal foods
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DOI: 10.1016/j.tifs.2020.08.018
Abstract: Abstract At present, there are many kinds of H1 receptor antagonists as medicinal foods in clinical application, which can be divided into ethylenediamine antagonist, aminoether antagonist, propylamine antagonist, tricyclic antagonist, piperazine antagonist and piperidine antagonist… read more here.
Keywords: antagonists medicinal; antagonist; medicinal foods; receptor antagonists ... See more keywords
A Chemical switch for transforming a purine agonist for Toll-like receptor 7 to a clinically relevant antagonist.
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DOI: 10.1021/acs.jmedchem.0c00011
Abstract: Toll-like receptor 7 (TLR7) is an established therapeutic target in myriad autoimmune disorders, but no TLR7 antagonist is available for clinical use to date. Herein we report a purine scaffold TLR7 antagonist, first-of-its-kind to our… read more here.
Keywords: toll like; chemical switch; like receptor; clinically relevant ... See more keywords