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   Articles with "antagonist" as a keyword



Metabolism Balance Regulation via Antagonist‐Functionalized Injectable Microsphere for Nucleus Pulposus Regeneration

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recommendations! Published in 2020 at "Advanced Functional Materials"

DOI: 10.1002/adfm.202006333

Abstract: Antagonist therapy represents a potential treatment for extracellular matrix (ECM) metabolic imbalance via the specific binding of inflammatory factors resulting from inflammation. However, the short half‐life of antagonist bioactivity creates challenges for their clinical application.… read more here.

Keywords: antagonist functionalized; functionalized injectable; antagonist; balance ... See more keywords

Selective adrenergic alpha2C receptor antagonist ameliorates acute phencyclidine-induced schizophrenia-like social interaction deficits in rats

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recommendations! Published in 2018 at "Psychopharmacology"

DOI: 10.1007/s00213-018-5130-2

Abstract: RationaleSocial withdrawal is a core feature of the negative symptoms of schizophrenia. Currently available pharmacotherapies have only limited efficacy towards the negative symptoms, i.e., there is a significant unmet medical need in the treatment of… read more here.

Keywords: interaction; interaction deficits; antagonist; receptor ... See more keywords

The Effects of Neurokinin-1 Receptor Antagonist in an Experimental Autoimmune Cystitis Model Resembling Bladder Pain Syndrome/Interstitial Cystitis

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recommendations! Published in 2018 at "Inflammation"

DOI: 10.1007/s10753-018-0888-2

Abstract: To identify the effects of the neurokinin-1 receptor (NK1R) antagonist aprepitant in treating pelvic pain, micturition symptoms, and bladder inflammation in mice with experimental autoimmune cystitis (EAC) similar to bladder pain syndrome/interstitial cystitis (BPS/IC). Female… read more here.

Keywords: cystitis; bladder; eac; mice ... See more keywords

The effects of a growth hormone-releasing hormone antagonist and a gastrin-releasing peptide antagonist on intimal hyperplasia of the carotid artery after balloon injury in a diabetic rat model

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recommendations! Published in 2017 at "Artery Research"

DOI: 10.1016/j.artres.2017.06.006

Abstract: Abstract Introduction Arterial restenosis after angioplasty/stenting has hindered coronary artery disease treatment, especially in diabetics. We theorized that gastrin-releasing peptide (GRP) antagonists and growth hormone-releasing hormone (GHRH) antagonists might decrease neointimal hyperplasia and restenosis in… read more here.

Keywords: artery; releasing peptide; antagonist; growth ... See more keywords

Dehydroepiandrosterone sulfate improves visceral sensation and gut barrier in a rat model of irritable bowel syndrome

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recommendations! Published in 2019 at "European Journal of Pharmacology"

DOI: 10.1016/j.ejphar.2019.03.037

Abstract: ABSTRACT Stress‐induced altered visceral sensation and impaired gut barrier play an important role in the pathophysiology of irritable bowel syndrome (IBS). These responses were demonstrated to be peripheral corticotropin‐releasing factor (CRF) dependent and also mediated… read more here.

Keywords: gut barrier; stress induced; model; antagonist ... See more keywords

The effect of the muscarinic M1 receptor antagonist biperiden on cognition in medication free subjects with psychosis

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recommendations! Published in 2017 at "European Neuropsychopharmacology"

DOI: 10.1016/j.euroneuro.2017.06.014

Abstract: The acetylcholine muscarinic M1 receptor has been implicated in both psychosis and cognition. Post-mortem research has shown reduced muscarinic M1 receptor density in 25% of chronic patients with schizophrenia. It is unknown whether reduced M1… read more here.

Keywords: muscarinic receptor; medication; antagonist; receptor ... See more keywords

NPS 2143, a selective calcium-sensing receptor antagonist inhibits lipopolysaccharide-induced pulmonary inflammation.

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recommendations! Published in 2017 at "Molecular immunology"

DOI: 10.1016/j.molimm.2017.07.012

Abstract: NPS 2143, a novel and selective antagonist of calcium-sensing receptor (CaSR) has been reported to possess anti-inflammatory activity. In the present study, we examined the protective effect of NPS 2143 on lipopolysaccharide (LPS)-induced acute lung… read more here.

Keywords: nps; nps 2143; antagonist; sensing receptor ... See more keywords

NMDA receptor antagonist rodent models for cognition in schizophrenia and identification of novel drug treatments, an update

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recommendations! Published in 2018 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2017.11.045

Abstract: &NA; Negative and cognitive deficit symptoms in schizophrenia remain an unmet clinical need. Improved understanding of the neuro‐ and psychopathology of cognitive dysfunction in the illness is urgently required to enhance the development of new… read more here.

Keywords: cognition schizophrenia; rodent; effects nmdar; antagonist ... See more keywords

The adenosine A2A receptor antagonist protects against retinal mitochondrial injury in association with an altered network of competing endogenous RNAs

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recommendations! Published in 2022 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2022.108981

Abstract: Blockade of adenosine A2A receptors (A2ARs) protects against neuronal damage caused by various brain insults including mitochondrial toxicity, but the precise neuroprotective mechanisms are unclear. Here, we studied the effects of the A2AR antagonist KW6002… read more here.

Keywords: retinal injury; injury; network; antagonist ... See more keywords

The antagonistic activity of H1 receptor antagonists as medicinal foods

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recommendations! Published in 2020 at "Trends in Food Science and Technology"

DOI: 10.1016/j.tifs.2020.08.018

Abstract: Abstract At present, there are many kinds of H1 receptor antagonists as medicinal foods in clinical application, which can be divided into ethylenediamine antagonist, aminoether antagonist, propylamine antagonist, tricyclic antagonist, piperazine antagonist and piperidine antagonist… read more here.

Keywords: antagonists medicinal; antagonist; medicinal foods; receptor antagonists ... See more keywords

Discovery and Characterization of Fluopipamine, a Putative Cellulose Synthase 1 Antagonist within Arabidopsis

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recommendations! Published in 2024 at "Journal of Agricultural and Food Chemistry"

DOI: 10.1021/acs.jafc.3c05199

Abstract: Herbicide-resistant weeds are increasingly a problem in crop fields when exposed to similar chemistry over time. To avoid future yield losses, identifying herbicidal chemistry needs to be accelerated. We screened 50,000 small molecules using a… read more here.

Keywords: chemistry; arabidopsis; antagonist; cellulose synthase ... See more keywords