Apo- and Antagonist-Binding Structures of Vitamin D Receptor Ligand-Binding Domain Revealed by a Combination Andlysis of MD Simulations and SAXS Experiments
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DOI: 10.1016/j.bpj.2016.11.298
Abstract: Vitamin D receptor (VDR) is a member of the nuclear receptor (NR) family and regulates the expression of genes related to calcium homeostasis , immunomodulation, and cell differentiation and proliferation. The VDR and other NRs… read more here.
Keywords: antagonist binding; form; crystal structures; ligand binding ... See more keywords
Impact of cancer-associated mutations in CC chemokine receptor 2 on receptor function and antagonism.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical pharmacology"
DOI: 10.2139/ssrn.4250690
Abstract: CC chemokine receptor 2 (CCR2), a G protein-coupled receptor, plays a role in many cancer-related processes such as metastasis formation and immunosuppression. Since ∼20% of human cancers contain mutations in G protein-coupled receptors, ten cancer-associated… read more here.
Keywords: impact cancer; chemokine receptor; cancer associated; receptor ... See more keywords