Conformationally Restricted σ1 Receptor Antagonists from (-)-Isopulegol.
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DOI: 10.1021/acs.jmedchem.2c02081
Abstract: Antagonists at σ1 receptors have great potential for the treatment of neuropathic pain. Starting from monoterpene (-)-isopulegol (1), aminodiols 8-11 were obtained and transformed into bicyclic 13-16 and tricyclic ligands 19-22. Aminodiols 8-11 showed higher… read more here.
Keywords: affinity; antagonists isopulegol; conformationally restricted; higher affinity ... See more keywords