Repurposing bortezomib for choroidal neovascularization treatment via antagonizing VEGF-A and PDGF-D mediated signaling.
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DOI: 10.1016/j.exer.2021.108446
Abstract: Neovascular age-related macular degeneration (neoAMD) is the leading cause of blindness in AMD and manifests as choroidal neovascularization (CNV). Anti-vascular endothelial growth factor (VEGF) therapies are the mainstay treatments but with limited efficacy and cause… read more here.
Keywords: choroidal neovascularization; antagonizing vegf; injection; cnv ... See more keywords