Environmentally-realistic concentrations of anthelmintic drugs affect survival and motility in the cosmopolitan earthworm Lumbricus terrestris (Linnaeus, 1758)
Sign Up to like & getrecommendations! Published in 2019 at "Applied Soil Ecology"
DOI: 10.1016/j.apsoil.2019.02.001
Abstract: Anthelmintic drugs are used to control intestinal parasitic worms in animals worldwide. Although generally effective in managing animal health, such treatment can introduce anthelminthic compounds to the wider environment as active ingredients and metabolites are… read more here.
Keywords: pyrantel; earthworm; environmentally realistic; motility ... See more keywords
A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing
Sign Up to like & getrecommendations! Published in 2019 at "International Journal for Parasitology: Drugs and Drug Resistance"
DOI: 10.1016/j.ijpddr.2019.04.001
Abstract: Infections with parasitic nematodes are among the most significant of the neglected tropical diseases affecting about a billion people living mainly in tropical regions with low economic activity. The most effective current strategy to control… read more here.
Keywords: leader trans; spliced leader; anthelmintic drugs; trans splicing ... See more keywords
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00823
Abstract: Transthyretin (TTR) is a causative protein of TTR amyloidosis (ATTR amyloidosis), a general term for diseases characterized by deposition of TTR amyloid fibrils in specific organs. ATTR amyloidosis can be ameliorated by stabilization of the… read more here.
Keywords: bithionol triclabendazole; ttr; drugs bithionol; amyloidosis ... See more keywords
Anthelmintic drugs for repurposing against Gram-negative bacilli infections.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220714092916
Abstract: Bacterial infections are among the leading causes of death worldwide. The emergence of antimicrobial resistance factors threatens the efficacy of all current antimicrobial agents, with some already made ineffective, and, as a result, there is… read more here.
Keywords: drug; anthelmintic drugs; negative bacilli; gram negative ... See more keywords
Susceptibility of Angiostrongylus cantonensis Larvae to Anthelmintic Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.901459
Abstract: Human helminthiasis affects approximately one in five people in the world and disproportionally affects the poorest and most deprived communities. Human angiostrongyliasis, caused by nematode Angiostrongylus cantonensis, is a neglected emerging disease with escalating importance… read more here.
Keywords: cantonensis; angiostrongylus cantonensis; susceptibility angiostrongylus; larvae anthelmintic ... See more keywords
Anthelmintic Drugs as Emerging Immune Modulators in Cancer
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076446
Abstract: Despite recent advances in treatment approaches, cancer is still one of the leading causes of death worldwide. Restoration of tumor immune surveillance represents a valid strategy to overcome the acquired resistance and cytotoxicity of conventional… read more here.
Keywords: emerging immune; modulators cancer; immune modulators; anthelmintic drugs ... See more keywords