Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne.
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DOI: 10.1021/acs.orglett.7b03120
Abstract: A new anthraquinone-fused enediyne, yangpumicin A (YPM A, 1), along with four Bergman cyclization congeners (YPM B-E, 2-5), was isolated from Micromonospora yangpuensis DSM 45577 after mining enediyne biosynthetic gene clusters from public actinobacterial genome… read more here.
Keywords: fused enediyne; anthraquinone fused; micromonospora yangpuensis; dsm 45577 ... See more keywords
Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes.
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DOI: 10.1021/jacs.1c03911
Abstract: Anthraquinone-fused enediynes (AQEs) are renowned for their distinctive molecular architecture, reactive enediyne warhead, and potent anticancer activity. Although the first members of AQEs, i.e., dynemicins, were discovered three decades ago, how their nitrogen-containing carbon skeleton… read more here.
Keywords: insights biosynthesis; anthraquinone fused; pathway retrofitting; fused enediynes ... See more keywords
Total Synthesis and Biological Evaluation of Tiancimycins A and B, Yangpumicin A, and Related Anthraquinone-Fused Enediyne Antitumor Antibiotics.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b12522
Abstract: The family of anthraquinone-fused enediyne antitumor antibiotics was established by the discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation of uncialamycin, and then by the addition to the… read more here.
Keywords: fused enediyne; anthraquinone fused; total synthesis; biology ... See more keywords