Development of a set of three real-time loop-mediated isothermal amplification (LAMP) assays for detection of Bacillus anthracis, the causative agent of anthrax.
Sign Up to like & getrecommendations! Published in 2021 at "Folia microbiologica"
DOI: 10.1007/s12223-021-00869-x
Abstract: Bacillus anthracis, the causative agent of anthrax is a Gram-positive, non-motile, spore forming bacterium. Its spores can persist in soil and water for years and can also be aerosolized. A rapid, sensitive and specific method… read more here.
Keywords: causative agent; bacillus anthracis; anthrax; amplification ... See more keywords
Dynamical analysis and control strategies in modeling anthrax
Sign Up to like & getrecommendations! Published in 2017 at "Computational and Applied Mathematics"
DOI: 10.1007/s40314-015-0297-1
Abstract: Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. It occurs most frequently as a disease of herbivores (e.g., cattle, goats and sheep) that acquire spores from direct contact with contaminated… read more here.
Keywords: spread anthrax; carcass disposal; anthrax; dynamical analysis ... See more keywords
Improving the stability of recombinant anthrax protective antigen vaccine.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.09.012
Abstract: Development of recombinant protective antigen (rPA)-based anthrax vaccines has been hindered by a lack of stability of the vaccines associated with spontaneous deamidation of asparagine (Asn) residues of the rPA antigen during storage. In this… read more here.
Keywords: protective antigen; anthrax; vaccine; stability ... See more keywords
Single Particle CryoEM of the Anthrax Toxin Initial Engagement Complex
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617006948
Abstract: The lethality of anthrax, a zoonotic disease and bioterrorism agent, is due to the anthrax toxin. This tripartitate toxin consists of protective antigen (PA), lethal factor (LF), and edema factor (EF). The 440 kDa heptameric… read more here.
Keywords: anthrax toxin; initial engagement; single particle; anthrax ... See more keywords
Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00184
Abstract: Anthrax, a lethal, weaponizable disease caused by Bacillus anthracis, acts through exotoxins that are primary mediators of systemic toxicity and also targets for neutralization by passive immunotherapy. The ease of engineering B. anthracis strains resistant… read more here.
Keywords: anthrax edema; discovery characterization; anthrax; antibody ... See more keywords
Single Low-Dose Nanovaccine for Long-Term Protection against Anthrax Toxins.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c03881
Abstract: Anthrax infections caused by Bacillus anthracis are an ongoing bioterrorism and livestock threat worldwide. Current approaches for management, including extended passive antibody transfusion, antibiotics, and prophylactic vaccination, are often cumbersome and associated with low patient… read more here.
Keywords: single low; anthrax toxins; nanovaccine long; anthrax ... See more keywords
Europium Functionalized Flexible Luminescent Zeolite-like Supramolecular Assembly for Ratiometric Anthrax Biomarker Determination.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b11650
Abstract: Anthrax spores have been a determining risk to human beings and animals across the world. As such, the qualitative monitoring towards dipicolinic acid (DPA), the unique biomarker of bacillus anthracis, is highly desired and being… read more here.
Keywords: zeolite like; biomarker; anthrax; supramolecular assembly ... See more keywords
The Impact of Protonation on Early Translocation of Anthrax Lethal Factor: Kinetics from Molecular Dynamics Simulations and Milestoning Theory.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b07419
Abstract: We report atomically detailed molecular dynamics simulations of the permeation of the lethal factor (LF) N-terminal segment through the anthrax channel. The N-terminal chain is unstructured and leads the permeation process for the LF protein.… read more here.
Keywords: molecular dynamics; anthrax; milestoning theory; protonation ... See more keywords
Epidemiology: Anthrax threatens wildlife
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Microbiology"
DOI: 10.1038/nrmicro.2017.100
Abstract: Anthrax is a bacterial disease that affects wild and domestic animals, as well as humans. Although outbreaks have mostly been reported in arid ecosystems of the African savannahs, lethal anthrax-like cases in wild chimpanzees were… read more here.
Keywords: threatens wildlife; epidemiology anthrax; anthrax; anthrax threatens ... See more keywords
Immunogenicity of anthrax recombinant peptides and killed spores in goats and protective efficacy of immune sera in A/J mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35382-8
Abstract: Anthrax is primarily recognized as an affliction of herbivores with incubation period ranging from three to five days post-infection. Currently, the Sterne live-spore vaccine is the only vaccine approved for control of the disease in… read more here.
Keywords: immune sera; immunogenicity; recombinant peptides; anthrax ... See more keywords
Bacillus anthracis induces NLRP3 inflammasome activation and caspase-8–mediated apoptosis of macrophages to promote lethal anthrax
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116415119
Abstract: Significance Anthrax is a deadly infection caused by exposure to Bacillus anthracis bacteria. Anthrax lethal toxin (LeTx) has long been recognized as a major determinant of lethal anthrax, which paralyzes the host’s immune defenses by… read more here.
Keywords: apoptosis; anthrax; inflammasome activation; nlrp3 inflammasome ... See more keywords