Single Particle CryoEM of the Anthrax Toxin Initial Engagement Complex
Sign Up to like & getrecommendations! Published in 2017 at "Microscopy and Microanalysis"
DOI: 10.1017/s1431927617006948
Abstract: The lethality of anthrax, a zoonotic disease and bioterrorism agent, is due to the anthrax toxin. This tripartitate toxin consists of protective antigen (PA), lethal factor (LF), and edema factor (EF). The 440 kDa heptameric… read more here.
Keywords: anthrax toxin; initial engagement; single particle; anthrax ... See more keywords
Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14658-6
Abstract: Following assembly, the anthrax protective antigen (PA) forms an oligomeric translocon that unfolds and translocates either its lethal factor (LF) or edema factor (EF) into the host cell. Here, we report the cryo-EM structures of… read more here.
Keywords: partially unfolded; protective antigen; anthrax toxin; edema ... See more keywords
Treatment of ovarian cancer with modified anthrax toxin
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210179119
Abstract: Many bacterial protein toxins are highly potent and extremely toxic cytocidal agents. With the discovery of toxin targets and the elucidation of molecular mechanisms of toxin action, the question arose of how to use these… read more here.
Keywords: masps; anthrax toxin; protease; toxin ... See more keywords
Structural basis for anthrax toxin receptor 1 recognition by Seneca Valley Virus.
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.2210/pdb6cx1/pdb
Abstract: Recently, the use of oncolytic viruses in cancer therapy has become a realistic therapeutic option. Seneca Valley Virus (SVV) is a newly discovered picornavirus, which has earned a significant reputation as a potent oncolytic agent.… read more here.
Keywords: toxin; anthrax toxin; structure; receptor ... See more keywords
A Dual Role for the Bacillus anthracis Master Virulence Regulator AtxA: Control of Sporulation and Anthrax Toxin Production
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.00482
Abstract: Bacillus anthracis is an endemic soil bacterium that exhibits two different lifestyles. In the soil environment, B. anthracis undergoes a cycle of saprophytic growth, sporulation, and germination. In mammalian hosts, the pathogenic lifestyle of B.… read more here.
Keywords: sporulation; virulence; bacillus anthracis; toxin ... See more keywords
Phage Display Analysis of Monoclonal Antibody Binding to Anthrax Toxin Lethal Factor
Sign Up to like & getrecommendations! Published in 2017 at "Toxins"
DOI: 10.3390/toxins9070221
Abstract: AVR1674 and AVR1675 are monoclonal antibodies (mAbs) that bind with high specificity to anthrax toxin lethal factor (LF) and lethal toxin (LTx). These mAbs have been used as pivotal reagents to develop anthrax toxin detection… read more here.
Keywords: analysis; phage; toxin; anthrax toxin ... See more keywords
Targeting Anthrax Toxin Receptor 2 Ameliorates Endometriosis Progression
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DOI: 10.7150/thno.30655
Abstract: Rationale: Endometriosis is a highly prevalent gynecological disease in women of reproductive age that markedly reduces life quality and fertility. Unfortunately, there is no cure for this disease, which highlights that more efforts are needed… read more here.
Keywords: receptor ameliorates; anthrax toxin; antxr2; targeting anthrax ... See more keywords