Solid Phase Immunoassay for the Detection of Anti-β2 Glycoprotein I Antibodies.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7196-1_17
Abstract: The discovery in the 1990s that the protein beta-2-glycoprotein I (β2GPI) was an antigen of central importance in the antiphospholipid syndrome (APS) was soon followed by the development of ELISA assays capable of identifying anti-β2GPI… read more here.
Keywords: anti 2gpi; solid phase; detection anti; anti glycoprotein ... See more keywords
Comorbid association of antiphospholipid antibodies and migraine: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Autoimmunity reviews"
DOI: 10.1016/j.autrev.2017.03.005
Abstract: BACKGROUND Antiphospholipid antibodies (aPLs) namely anticardiolipin (aCL) antibody, anti-β2-glycoprotein I (β2GPI) antibody and lupus anticoagulant (LA) are autoantibodies produced against anionic phospholipids and proteins on plasma membranes. Migraine is a primary headache disorder which has… read more here.
Keywords: migraine; anti 2gpi; healthy controls; comorbid association ... See more keywords
The role of thrombospondin-1 in the pathogenesis of antiphospholipid syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2020.102527
Abstract: OBJECTIVE Antiphospholipid syndrome (APS) is an acquired thrombophilia characterized by recurrent thrombosis and/or pregnancy morbidity, in the presence of antibodies to β2 glycoprotein-I (β2GPI), prothrombin or Lupus anticoagulant (LA). Anti-β2GPI antibodies recognize complexes of β2GPI… read more here.
Keywords: tsp levels; 2gpi cxcl4; antiphospholipid syndrome; anti 2gpi ... See more keywords
Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome.
Sign Up to like & getrecommendations! Published in 2022 at "Platelets"
DOI: 10.1080/09537104.2022.2156492
Abstract: Platelet microparticles (PMPs) are vesicles that are released by platelets into the extracellular space and play a role in antiphospholipid antibody syndromes. PMPs have recently been recognized as a new and viable cell. There is… read more here.
Keywords: endothelial cells; pyroptosis endothelial; 2gpi complexes; 2gpi 2gpi ... See more keywords
AB0566 Anti-phospholipid antibodies sero-negativization in systemic lupus erythematosus patients treated with belimumab
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.6269
Abstract: Background Belimumab is a monoclonal antibody that blocks the B lymphocyte stimulator, preventing it to bind its receptor on B-lymphocyte’s surface, thus avoiding B cell activation. Despite some benefits showed in murine models of anti… read more here.
Keywords: anti 2gpi; igg; belimumab; acl ... See more keywords
Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS.
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood.2019003863
Abstract: The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies including anti-beta-2-glycoprotein-I (anti-β2GPI) that are considered central to APS pathogenesis. Based on animal studies showing a role of… read more here.
Keywords: 2gpi antibodies; anti 2gpi; complement regulatory; complement ... See more keywords
Anti-β2GPI/β2GPI induces neutrophil pyroptosis and thereby enhances ICAM-1 and IL-8 expression in endothelial cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2022.5120
Abstract: Anti-β2-glycoprotein I (anti-β2GPI) is an anti-phospholipid antibody that specifically binds to β2GPI. There is growing evidence that this autoantibody is closely linked to specific thrombotic conditions. Cerebral infarction (CI) is a form of thrombosis associated… read more here.
Keywords: neutrophil pyroptosis; expression; pyroptosis thereby; 2gpi 2gpi ... See more keywords