Quantification of anti-aggregation activity of chaperones.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2016.07.066
Abstract: Anti-aggregation potential of the cell is determined by chaperones of a proteinaceous nature (mainly by small heat shock proteins) and low-molecular-weight chemical chaperones. To characterize the anti-aggregation activity of chaperones in vitro, appropriate test systems… read more here.
Keywords: aggregation activity; aggregation; kls; anti aggregation ... See more keywords
Rational approach for design and evaluation of anti-aggregation agents for protein stabilization: A case study of trehalose phenylalaninate.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.03.075
Abstract: The present work introduces new anti-aggregation agent (AAA) derived through our new approach for design and evaluation of anti-aggregation agent as a multi-purpose excipient to combat protein aggregation. Therapeutic proteins undergo aggregation due to even… read more here.
Keywords: aggregation; tpa; approach design; anti aggregation ... See more keywords
Anti-aggregation Effects of Phenolic Compounds on α-synuclein
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25102444
Abstract: The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the… read more here.
Keywords: aggregation; aggregation effects; anti aggregation; phenolic compounds ... See more keywords
Design, Synthesis, and Neuroprotective Activity of Phenoxyindole Derivatives on Antiamyloid Beta (Aβ) Aggregation, Antiacetylcholinesterase, and Antioxidant Activities
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceuticals"
DOI: 10.3390/ph16030355
Abstract: In this investigation, a number of phenoxyindole derivatives were designed, synthesized, and tested for their neuroprotective ability on SK-N-SH cells against Aβ42-induced cell death and biologically specific activities involved in anti-Aβ aggregation, anti-AChE, and antioxidant… read more here.
Keywords: design synthesis; aggregation; compound; phenoxyindole derivatives ... See more keywords