Peripheral and central sites of action for anti‐allodynic activity induced by the bifunctional opioid/NPFF receptors agonist BN‐9 in inflammatory pain model
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.07.044
Abstract: ABSTRACT The activation of opioid and neuropeptide FF (NPFF) receptors plays important roles to modulate nociceptive signal in inflammatory pain states. Recently, BN‐9 (Tyr‐D. Ala‐Gly‐Phe‐Gln‐Pro‐Gln‐Arg‐Phe‐NH2) was pharmacologically characterized as a novel bifunctional agonist at both… read more here.
Keywords: anti allodynic; inflammatory pain; model; npff receptors ... See more keywords
Examination of the Novel Sigma-1 Receptor Antagonist, SI 1/28, for Antinociceptive and Anti-allodynic Efficacy against Multiple Types of Nociception with Fewer Liabilities of Use
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23020615
Abstract: Neuropathic pain is a significant problem with few effective treatments lacking adverse effects. The sigma-1 receptor (S1R) is a potential therapeutic target for neuropathic pain, as antagonists for this receptor effectively ameliorate pain in both… read more here.
Keywords: antinociceptive anti; anti allodynic; nociception; pain ... See more keywords