In vitro enzymatic evaluation of some pyrazolo[1,5‐a]pyrimidine derivatives: Design, synthesis, antioxidant, anti‐diabetic, anti‐Alzheimer, and anti‐arthritic activities with molecular modeling simulation
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22008
Abstract: The strategy of utilizing nitrogen compounds in various biological applications has recently emerged as a powerful approach to exploring novel classes of therapeutics to face the challenge of diseases. A series of pyrazolo[1,5‐a]pyrimidine‐based compounds 3a–l… read more here.
Keywords: anti alzheimer; pyrazolo pyrimidine; anti diabetic; diabetic anti ... See more keywords
Potential of flavonoids as anti-Alzheimer’s agents: bench to bedside
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-021-18165-z
Abstract: Developing therapies for neurodegenerative diseases are challenging because of the presence of blood–brain barrier and Alzheimer being one of the commonest and uprising neurodegenerative disorders possess the need for developing novel therapies. Alzheimer’s is attributed… read more here.
Keywords: anti alzheimer; agents bench; bench bedside; flavonoids anti ... See more keywords
Anti-Alzheimer, antidiabetic and antioxidant potential of Satureja cuneifolia and analysis of its phenolic contents by LC-MS/MS
Sign Up to like & getrecommendations! Published in 2020 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2019.10.002
Abstract: Abstract Many chronic diseases such as diabetes and Alzheimer’s disease are related to the type and quality of foods, which are consumed. Particularly, various plant origin products are stated as beneficial against such kind of… read more here.
Keywords: cuneifolia; plant; analysis phenolic; satureja cuneifolia ... See more keywords
Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.102960
Abstract: In a search for novel multifunctional anti-Alzheimer agents, a congeneric set of seventeen flavone-8-acrylamide derivatives (8a─q) were synthesized and evaluated for their cholinesterase inhibitory, antioxidant, neuroprotective and modulation of Aβ aggregation activities. The target compounds… read more here.
Keywords: acrylamide derivatives; alzheimer agents; flavone acrylamide; anti alzheimer ... See more keywords
Novel carbazole-stilbene hybrids as multifunctional anti-Alzheimer agents.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103977
Abstract: Molecules capable of engaging with multiple targets associated with pathological condition of Alzheimer's disease have proved to be potential anti-Alzheimer's agents. In our goal to develop multitarget-directed ligands for the treatment of Alzheimer's disease, a… read more here.
Keywords: novel carbazole; carbazole stilbene; anti alzheimer; alzheimer ... See more keywords
Cadinane-type sesquiterpenes from the resinous exudates of Commiphora myrrha and their anti-Alzheimer's disease bioactivities.
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104536
Abstract: Commiphoins A-C (1-3), three new cadinane-type sesquiterpenes, together with two known cadinane-type sesquiterpenes (4 and 5) were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were established on the basis… read more here.
Keywords: resinous exudates; type sesquiterpenes; commiphora myrrha; exudates commiphora ... See more keywords
Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2019.05.080
Abstract: Abstract The aerial parts of Lamiaceae plants have been used since ancient times all over the world, especially in Mediterranean cultures, for their medicinal and culinary properties. Although some of them have a historical role… read more here.
Keywords: kinase; anti alzheimer; alzheimer effects; potential anti ... See more keywords
Hydroxyphenylamine phosphonate derivatives: Synthesis, X-ray crystallographic analysis, and evaluation of theirs anti-Alzheimer effects and antioxidant activities
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129121
Abstract: Abstract The present study deals with the synthesis and characterization by single-crystal X-ray analysis, UV-Vis and FT-IR spectroscopy of two new α-aminophosphonates molecules: ((2-Hydroxy-5-methyl-phenylamino)-phenyl-methyl)-phosphonic acid diethyl ester (MAPH) and ((2-Hydroxy-5-nitro-phenylamino)-phenyl-methyl)-phosphonic acid diethyl ester (NAPH), based… read more here.
Keywords: analysis; phosphonate derivatives; maph; two molecules ... See more keywords
In vitro examination of anti-parasitic, anti-Alzheimer, insecticidal and cytotoxic potential of Ajuga bracteosa Wallich leaves extracts
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.02.044
Abstract: This research study is mainly focused to evaluate the anti-parasitic, insecticidal, cytotoxic and anti-alzheimer potential of various leaf extracts of Ajuga bracteosa Wallich ex Bentham. 04 different extracts were prepared using solvent of different polarity… read more here.
Keywords: ajuga bracteosa; anti parasitic; insecticidal cytotoxic; anti alzheimer ... See more keywords
Novel benzylated (pyrrolidin-2-one) / (imidazolidin-2-one) derivatives as potential Anti-Alzheimer's agents: Synthesis and Pharmacological investigations.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00403
Abstract: A series of N-benzylated (pyrrolidin-2-one) / (imidazolidin-2-one) derivatives were synthesized and evaluated for anti-Alzheimer's activity. The analogs were designed and synthesized based on lead compound donepezil, which is currently prescribed as a major drug for… read more here.
Keywords: benzylated pyrrolidin; one imidazolidin; pyrrolidin one; imidazolidin one ... See more keywords
Donepezil-Inspired Multitargeting Indanone Derivatives as Effective Anti-Alzheimer's Agents.
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DOI: 10.1021/acschemneuro.1c00535
Abstract: In continuous efforts to develop anti-Alzheimer's agents, we rationally designed and synthesized a series of multitargeting molecules by incorporating the essential molecular features of the standard drug donepezil. Among the series, compound 4b showed multitargeting… read more here.
Keywords: anti alzheimer; donepezil inspired; compound; alzheimer agents ... See more keywords