Efficacy and safety of anti‐amyloid‐β immunotherapy for Alzheimer's disease: a systematic review and network meta‐analysis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.469
Abstract: To review the optimality and safety of different anti‐Amyloid‐β(Aβ) immunotherapies for Alzheimer's disease (AD). Published randomized controlled trials were comprehensively reviewed from electronic databases (Cochrane library, Embase, Pubmed, and Google scholar). Pooled outcomes as mean… read more here.
Keywords: network; alzheimer disease; safety; review ... See more keywords
Transthyretin Mimetics as Anti‐β‐Amyloid Agents: A Comparison of Peptide and Protein Approaches
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800031
Abstract: β‐Amyloid (Aβ) aggregation is causally linked to neuronal pathology in Alzheimer's disease; therefore, several small molecules, antibodies, and peptides have been tested as anti‐Aβ agents. We developed two compounds based on the Aβ‐binding domain of… read more here.
Keywords: protein; mimetics anti; transthyretin mimetics; cg8 ... See more keywords
Passive Anti-amyloid Beta Monoclonal Antibodies: Lessons Learned over Past 20 Years
Sign Up to like & getrecommendations! Published in 2024 at "Neurology and Therapy"
DOI: 10.1007/s40120-024-00664-z
Abstract: Alzheimer’s disease (AD) is a neurodegenerative disorder that significantly impairs cognitive and functional abilities, placing a substantial burden on both patients and caregivers. Current symptomatic treatments fail to halt the progression of AD, highlighting the… read more here.
Keywords: anti amyloid; amyloid beta; lessons learned; beta monoclonal ... See more keywords
Extracts from Chinese herbs with anti-amyloid and neuroprotective activities.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.03.013
Abstract: Many Chinese herbs are well known for their neuroprotective and anti-oxidant properties. Extracts of Salvia miltiorrhiza and Anemarrhenae asphodeloides, tanshinone IIA (tanIIA), salvianolic acid B (Sal B) and sarsasapogenin (ML-1), were selected to study their… read more here.
Keywords: neuroprotective activities; herbs anti; chinese herbs; extracts chinese ... See more keywords
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
Sign Up to like & getrecommendations! Published in 2021 at "Nature chemistry"
DOI: 10.1038/s41557-021-00648-8
Abstract: A major role for the intracellular post-translational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous studies in this area focused on O-GlcNAc modification of the amyloid-forming proteins themselves. Here… read more here.
Keywords: glcnac; glcnac modification; small heat; chemistry ... See more keywords
Diphenylalanin Nanofibers-Inspired Synthesis of Fluorescent Gold Nanoclusters For Screening Of Anti-Amyloid drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Methods and applications in fluorescence"
DOI: 10.1088/2050-6120/ab9fef
Abstract: Protein misfolding and aggregation into amyloid structures is linked with a number of pathophysiological disorders. In the past decade, significant progresses have been made in the drug discovery strategies against toxic aggregates. Although lack of… read more here.
Keywords: diphenylalanin nanofibers; gold nanoclusters; nanofibers inspired; amyloid drugs ... See more keywords
Second-generation anti-amyloid monoclonal antibodies for Alzheimer’s disease: current landscape and future perspectives
Sign Up to like & getrecommendations! Published in 2025 at "Translational Neurodegeneration"
DOI: 10.1186/s40035-025-00465-w
Abstract: Alzheimer’s disease (AD) is the most common type of dementia. Monoclonal antibodies (MABs) serve as a promising therapeutic approach for AD by selectively targeting key pathogenic factors, such as amyloid-β (Aβ) peptide, tau protein, and… read more here.
Keywords: alzheimer disease; generation; second generation; anti amyloid ... See more keywords
β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201043
Abstract: Background and Objectives ATN (β-amyloid [Aβ], tau, neurodegeneration) system categorizes individuals based on their core Alzheimer disease (AD) biomarkers. An important potential future use for ATN is therapeutic decision-making in clinical practice once disease-modifying treatments… read more here.
Keywords: eligibility; amyloid treatment; anti amyloid; treatment ... See more keywords
Brain Shrinkage in Anti–β-Amyloid Alzheimer Trials
Sign Up to like & getrecommendations! Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000207268
Abstract: One of the puzzling observations from anti–amyloid-β therapeutic trials for Alzheimer disease (AD) has been that treated arms fail to show preservation of brain volume. In this issue of Neurology®, Alves et al.1 presented a… read more here.
Keywords: shrinkage anti; neurology; brain shrinkage; brain ... See more keywords
If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001694
Abstract: Strong genetic evidence supports an imbalance between production and clearance of amyloid β-protein (Aβ) in people with Alzheimer disease (AD). Microglia that are potentially involved in alternative mechanisms are actually integral to the amyloid cascade.… read more here.
Keywords: amyloid therapies; alzheimer disease; amyloid drives; anti amyloid ... See more keywords
Optimal anti-amyloid-beta therapy for Alzheimer’s disease via a personalized mathematical model
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010481
Abstract: With the recent approval by the FDA of the first disease-modifying drug for Alzheimer’s Disease (AD), personalized medicine will be increasingly important for appropriate management and counseling of patients with AD and those at risk.… read more here.
Keywords: beta therapy; amyloid beta; disease; anti amyloid ... See more keywords