Efficacy and safety of anti‐amyloid‐β immunotherapy for Alzheimer's disease: a systematic review and network meta‐analysis
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.469
Abstract: To review the optimality and safety of different anti‐Amyloid‐β(Aβ) immunotherapies for Alzheimer's disease (AD). Published randomized controlled trials were comprehensively reviewed from electronic databases (Cochrane library, Embase, Pubmed, and Google scholar). Pooled outcomes as mean… read more here.
Keywords: network; alzheimer disease; safety; review ... See more keywords
Transthyretin Mimetics as Anti‐β‐Amyloid Agents: A Comparison of Peptide and Protein Approaches
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800031
Abstract: β‐Amyloid (Aβ) aggregation is causally linked to neuronal pathology in Alzheimer's disease; therefore, several small molecules, antibodies, and peptides have been tested as anti‐Aβ agents. We developed two compounds based on the Aβ‐binding domain of… read more here.
Keywords: protein; mimetics anti; transthyretin mimetics; cg8 ... See more keywords
Extracts from Chinese herbs with anti-amyloid and neuroprotective activities.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2021.03.013
Abstract: Many Chinese herbs are well known for their neuroprotective and anti-oxidant properties. Extracts of Salvia miltiorrhiza and Anemarrhenae asphodeloides, tanshinone IIA (tanIIA), salvianolic acid B (Sal B) and sarsasapogenin (ML-1), were selected to study their… read more here.
Keywords: neuroprotective activities; herbs anti; chinese herbs; extracts chinese ... See more keywords
O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity
Sign Up to like & getrecommendations! Published in 2021 at "Nature chemistry"
DOI: 10.1038/s41557-021-00648-8
Abstract: A major role for the intracellular post-translational modification O-GlcNAc appears to be the inhibition of protein aggregation. Most of the previous studies in this area focused on O-GlcNAc modification of the amyloid-forming proteins themselves. Here… read more here.
Keywords: glcnac; glcnac modification; small heat; chemistry ... See more keywords
Diphenylalanin Nanofibers-Inspired Synthesis of Fluorescent Gold Nanoclusters For Screening Of Anti-Amyloid drugs.
Sign Up to like & getrecommendations! Published in 2020 at "Methods and applications in fluorescence"
DOI: 10.1088/2050-6120/ab9fef
Abstract: Protein misfolding and aggregation into amyloid structures is linked with a number of pathophysiological disorders. In the past decade, significant progresses have been made in the drug discovery strategies against toxic aggregates. Although lack of… read more here.
Keywords: diphenylalanin nanofibers; gold nanoclusters; nanofibers inspired; amyloid drugs ... See more keywords
β-Amyloid, Tau, Neurodegeneration Classification and Eligibility for Anti-amyloid Treatment in a Memory Clinic Population
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000201043
Abstract: Background and Objectives ATN (β-amyloid [Aβ], tau, neurodegeneration) system categorizes individuals based on their core Alzheimer disease (AD) biomarkers. An important potential future use for ATN is therapeutic decision-making in clinical practice once disease-modifying treatments… read more here.
Keywords: eligibility; amyloid treatment; anti amyloid; treatment ... See more keywords
Brain Shrinkage in Anti–β-Amyloid Alzheimer Trials
Sign Up to like & getrecommendations! Published in 2023 at "Neurology"
DOI: 10.1212/wnl.0000000000207268
Abstract: One of the puzzling observations from anti–amyloid-β therapeutic trials for Alzheimer disease (AD) has been that treated arms fail to show preservation of brain volume. In this issue of Neurology®, Alves et al.1 presented a… read more here.
Keywords: shrinkage anti; neurology; brain shrinkage; brain ... See more keywords
If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline?
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001694
Abstract: Strong genetic evidence supports an imbalance between production and clearance of amyloid β-protein (Aβ) in people with Alzheimer disease (AD). Microglia that are potentially involved in alternative mechanisms are actually integral to the amyloid cascade.… read more here.
Keywords: amyloid therapies; alzheimer disease; amyloid drives; anti amyloid ... See more keywords
Optimal anti-amyloid-beta therapy for Alzheimer’s disease via a personalized mathematical model
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1010481
Abstract: With the recent approval by the FDA of the first disease-modifying drug for Alzheimer’s Disease (AD), personalized medicine will be increasingly important for appropriate management and counseling of patients with AD and those at risk.… read more here.
Keywords: beta therapy; amyloid beta; disease; anti amyloid ... See more keywords
Are we ready to use anti-amyloid therapy in Alzheimer's disease?
Sign Up to like & getrecommendations! Published in 2022 at "Arquivos de Neuro-Psiquiatria"
DOI: 10.1590/0004-282x-anp-2022-s117
Abstract: ABSTRACT Alzheimer’s disease (AD) is the most common neurodegenerative disease. Biomarkers have demonstrated that AD pathology exists over the disease continuum from a stage preceding symptoms over 15-25 years to the progressively more impaired symptomatic… read more here.
Keywords: disease; alzheimer disease; amyloid therapy; anti amyloid ... See more keywords
Unveiling the Potential of Polyphenols as Anti-Amyloid Molecules in Alzheimer's Disease.
Sign Up to like & getrecommendations! Published in 2022 at "Current neuropharmacology"
DOI: 10.2174/1570159x20666221010113812
Abstract: Alzheimer's disease (AD) is a devastating neurodegenerative disease that mostly affects the elderly population. Mechanisms underlying AD pathogenesis are yet to be fully revealed, but there are several hypotheses regarding AD. Even though free radicals… read more here.
Keywords: disease; alzheimer disease; polyphenols anti; potential polyphenols ... See more keywords