Neuroblastoma SH-SY5Y cytotoxicity, anti-amyloidogenic activity and cyclooxygenase inhibition of Lasianthus trichophlebus (Rubiaceae)
Sign Up to like & getrecommendations! Published in 2020 at "3 Biotech"
DOI: 10.1007/s13205-020-2145-2
Abstract: The anti-amyloidogenic potential and cyclooxygenase anti-inflammatory activity of Lasianthus trichophlebus extracts were evaluated. The MeOH extract (LTM) and chloroform extract (LTC) exhibited significant cytotoxic inhibition against the neuroblastoma SH-SY5Y cell with an IC50 of 17.52… read more here.
Keywords: cyclooxygenase; lasianthus trichophlebus; inhibition; cyclooxygenase inhibition ... See more keywords
Investigation of the chemical structure of anti-amyloidogenic constituents extracted from Thamnolia vermicularis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2022.115059
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Thamnolia vermicularis (Sw.) Schaer (T. vermicularis) is known to have therapeutic effects on various diseases in Southwest China. Recent research has highlighted that T. vermicularis may suppress Aβ level and Tau hyperphosphorylation to… read more here.
Keywords: sfe co2; vermicularis; thamnolia vermicularis; structure ... See more keywords
Trehalose Conjugated, Catechin Loaded Polylactide Nanoparticle for Improved Neuroprotection against Intracellular Polyglutamine Aggregate.
Sign Up to like & getrecommendations! Published in 2020 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.0c00143
Abstract: Intracellular/extracellular protein aggregation is linked to variety of neurodegenerative diseases. Current research focusses on identifying anti-amyloidogenic small molecules to inhibit such protein aggregation and associated cytotoxicity. We have recently demonstrated that transforming those anti-amyloidogenic small… read more here.
Keywords: aggregation; nanoparticle improved; improved neuroprotection; nanoparticle ... See more keywords
Gastrokine-1, an anti-amyloidogenic protein secreted by the stomach, regulates diet-induced obesity
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88928-8
Abstract: Obesity and its sequelae have a major impact on human health. The stomach contributes to obesity in ways that extend beyond its role in digestion, including through effects on the microbiome. Gastrokine-1 (GKN1) is an… read more here.
Keywords: amyloidogenic protein; gkn1; secreted stomach; obesity ... See more keywords
Amyposomes, a nanotechnological chaperone with anti-amyloidogenic activity
Sign Up to like & getrecommendations! Published in 2023 at "Annals of Medicine"
DOI: 10.1080/07853890.2023.2205659
Abstract: Abstract Aim The effect of liposomes bi-functionalized with phosphatidic acid and with a synthetic peptide derived from human apolipoprotein E has been evaluated on the aggregation features of different amyloidogenic proteins: human Amyloid β1–40 (Aβ1–40),… read more here.
Keywords: amyposomes nanotechnological; protein misfolding; amyloidogenic activity; anti amyloidogenic ... See more keywords
Experimental and theoretical studies on the anti-amyloidogenic and destabilizing effects of pyrogallol against human insulin protein.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of food biochemistry"
DOI: 10.20944/preprints202202.0012.v1
Abstract: One of the major problems caused by repeated subcutaneous insulin injections in patients with diabetes is insulin amyloidosis. Understanding the molecular mechanism of amyloid fibril formation of insulin and finding effective compounds to inhibit or… read more here.
Keywords: spectroscopy; amyloidogenic destabilizing; insulin; protein ... See more keywords
NMR-Driven Identification of Cinnamon Bud and Bark Components With Anti-Aβ Activity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.896253
Abstract: The anti-Alzheimer disease (AD) activity reported for an aqueous cinnamon bark extract prompted us to investigate and compare the anti-amyloidogenic properties of cinnamon extracts obtained from both bark and bud, the latter being a very… read more here.
Keywords: cinnamon; activity; anti amyloidogenic; bud bark ... See more keywords
The Clustering of mApoE Anti-Amyloidogenic Peptide on Nanoparticle Surface Does Not Alter Its Performance in Controlling Beta-Amyloid Aggregation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21031066
Abstract: The deposition of amyloid-β (Aβ) plaques in the brain is a significant pathological signature of Alzheimer’s disease, correlating with synaptic dysfunction and neurodegeneration. Several compounds, peptides, or drugs have been designed to redirect or stop… read more here.
Keywords: aggregation; peptide; clustering mapoe; performance controlling ... See more keywords
The Cleavage-Specific Tau 12A12mAb Exerts an Anti-Amyloidogenic Action by Modulating the Endocytic and Bioenergetic Pathways in Alzheimer’s Disease Mouse Model
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119683
Abstract: Beyond deficits in hippocampal-dependent episodic memory, Alzheimer’s Disease (AD) features sensory impairment in visual cognition consistent with extensive neuropathology in the retina. 12A12 is a monoclonal cleavage specific antibody (mAb) that in vivo selectively neutralizes… read more here.
Keywords: specific tau; alzheimer disease; cleavage specific; model ... See more keywords
Anti-Amyloidogenic Effects of Metasequoia glyptostroboides Fruits and Its Active Constituents
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031017
Abstract: Alzheimer’s disease (AD) is a serious neurodegenerative brain disease that interferes with daily life. The accumulation of beta-amyloid (Aβ), along with oxidative stress-inducing neurocellular apoptosis, has been considered one of the causes of AD. Thus,… read more here.
Keywords: metasequoia glyptostroboides; glyptostroboides fruits; five compounds; effects metasequoia ... See more keywords
Pandanus amaryllifolius Exhibits In Vitro Anti-Amyloidogenic Activity and Promotes Neuroprotective Effects in Amyloid-β-Induced SH-SY5Y Cells
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14193962
Abstract: Accumulation of amyloid-beta (Aβ) plaques leading to oxidative stress, mitochondrial damage, and cell death is one of the most accepted pathological hallmarks of Alzheimer’s disease (AD). Pandanus amaryllifolius, commonly recognized as fragrant screw pine due… read more here.
Keywords: sy5y cells; neuroprotective effects; vitro anti; cbe ... See more keywords