The anti-androgenic effects of cypermethrin mediated by non-classical testosterone pathway activation of mitogen-activated protein kinase cascade in mouse Sertoli cells.
Sign Up to like & getrecommendations! Published in 2019 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2019.03.109
Abstract: Previous studies have demonstrated that the anti-androgenic effects of cypermethrin (CYP) are associated with testosterone (T) - related signaling pathway. This study was to investigate the effects of CYP on mouse Sertoli cells (TM4) and… read more here.
Keywords: non classical; sertoli cells; pathway; anti androgenic ... See more keywords
Pharmacokinetics of the anti-androgenic drug flutamide in healthy stallions.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary journal"
DOI: 10.1016/j.tvjl.2017.06.001
Abstract: Alternatives to surgical castration are necessary for controlling the sexual behaviour of stallions with breeding potential in training and competition. Flutamide is a potent selective non-steroidal androgen receptor competitive antagonist that has been used in… read more here.
Keywords: administration; androgenic drug; horses 5mg; drug ... See more keywords
Evaluation of (Anti)androgenic Activities of Environmental Xenobiotics in Milk Using a Human Liver Cell Line and Androgen Receptor-Based Promoter-Reporter Assay
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c05344
Abstract: The recent reports on milk consumption and its associated risk with hormone related disorders necessitates the evaluation of dairy products for the presence of endocrine disrupting chemicals (EDCs) and ensure the safety of consumers. In… read more here.
Keywords: anti androgenic; cell line; milk; androgenic activities ... See more keywords
Anti-androgenic therapy with finasteride in patients with chronic heart failure - a retrospective propensity score based analysis
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46640-8
Abstract: Sex hormones influence the prevalence and the outcome of heart diseases. The conversion of testosterone to its more active metabolite dihydrotestosterone drives cardiac growth and dysfunction, while inhibition of this step by the anti-androgenic drug… read more here.
Keywords: heart; analysis; finasteride; heart failure ... See more keywords
Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data
Sign Up to like & getrecommendations! Published in 2019 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfy245
Abstract: Abstract This study investigated the use of androgen receptor (AR) reporter gene assay data in a non-animal exposure-led risk assessment in which in vitro anti-androgenic activity and exposure data were put into context using a… read more here.
Keywords: risk; employing dietary; exposure; dietary comparators ... See more keywords
Presence of Bisphenol A and Parabens in a Neonatal Intensive Care Unit: An Exploratory Study of Potential Sources of Exposure.
Sign Up to like & getrecommendations! Published in 2019 at "Environmental health perspectives"
DOI: 10.1289/ehp-embargotest
Abstract: BACKGROUND Newborns in neonatal intensive care units (NICUs) are in contact with a variety of medical products whose production might include synthetic chemicals with hormonal activity. OBJECTIVES Our aim was to assess the content of… read more here.
Keywords: bisphenol; intensive care; activity; anti androgenic ... See more keywords