H2‐P, a honokiol derivative, exerts anti‐angiogenesis effects via c‐MYC signaling pathway in glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26462
Abstract: H2‐P, a derivative of honokiol, was first synthesized in our laboratory. Compared with honokiol, H2‐P has even high anti‐tumor activity. In the present study, we evaluated the ability of H2‐P to inhibit the survival rate… read more here.
Keywords: via myc; anti angiogenesis; angiogenesis; myc signaling ... See more keywords
A mathematical model of angiogenesis and tumor growth: analysis and application in anti-angiogenesis therapy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Mathematical Biology"
DOI: 10.1007/s00285-018-1264-4
Abstract: The purpose of this paper is to develop a new coupled mathematical model of angiogenesis (new blood vessel growth) and tumor growth to study cancer development and anti-angiogenesis therapy. The angiogenesis part assumes the capillary… read more here.
Keywords: anti angiogenesis; angiogenesis; analysis; model ... See more keywords
Anti-angiogenesis for cancer revisited: Is there a role for combinations with immunotherapy?
Sign Up to like & getrecommendations! Published in 2017 at "Angiogenesis"
DOI: 10.1007/s10456-017-9552-y
Abstract: Angiogenesis is defined as the formation of new blood vessels from preexisting vessels and has been characterized as an essential process for tumor cell proliferation and viability. This has led to the development of pharmacological… read more here.
Keywords: cancer revisited; anti angiogenesis; angiogenesis; angiogenesis cancer ... See more keywords
pH-responsive carboxymethyl chitosan-derived micelles as apatinib carriers for effective anti-angiogenesis activity: Preparation and in vitro evaluation.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.08.011
Abstract: In this study, carboxymethyl chitosan-graft-poly-(ε-caprolactone) copolymers (CMCS-g-PCL) were synthesized and used to encapsulate apatinib to prepare apatinib-loaded CMCS-g-PCL (CPA) micelles. CPA micelles' sizes were 100-150nm at pH 7.4 while aggregated to 300-350nm at pH 6.4,… read more here.
Keywords: cpa micelles; carboxymethyl chitosan; anti angiogenesis; cmcs pcl ... See more keywords
Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.10.030
Abstract: Herein, we embarked on a structural optimization campaign aiming at the discovery of second generation anti-angiogenesis agents with our previously reported BPS-7 as lead compound. A library of 27 compounds has been afforded based on… read more here.
Keywords: anti angiogenesis; tie ephb4; novel anti; angiogenesis agents ... See more keywords
Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.048
Abstract: A series of 2,4-diarylaminopyrimidine derivatives containing dithiocarbamate moiety were designed by molecular hybridization strategy and synthesized for screening as inhibitors of focal adhesion kinase (FAK). Most of these compounds exhibit significant antiproliferative activities on human… read more here.
Keywords: diarylaminopyrimidine derivatives; dithiocarbamate moiety; anti angiogenesis;
Design, synthesis, and in vitro and in vivo anti-angiogenesis study of a novel vascular endothelial growth factor receptor-2 (VEGFR-2) inhibitor based on 1,2,3-triazole scaffold.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113083
Abstract: In the past five years, our team had been committed to click chemistry research, exploring the biological activity of 1,2,3-triazole by synthesizing different target inhibitors. In this study, a series of novel indole-2-one derivatives based… read more here.
Keywords: anti angiogenesis; chemistry; compound 13d; vegfr ... See more keywords
Screening and identification of Euphorbiae pekinensis Rupr. anti-angiogenic multi-components with UPLC-QTOF-MS in zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2021.114396
Abstract: Euphorbia pekinensis Rupr. (EP) (Euphorbiaceae), as Traditional Chinese Medicine (TCM), exhibits therapeutic effects on tumors in clinical practice. Anti-angiogenesis may be an underlying molecular mechanism of EP's actions. However, the anti-angiogenic active ingredients of EP… read more here.
Keywords: anti angiogenesis; components uplc; uplc qtof; pekinensis rupr ... See more keywords
Lactobacillus acidophilus and Bifidobacterium longum exhibit antiproliferation, anti-angiogenesis of gastric and bladder cancer: Impact of COX2 inhibition
Sign Up to like & getrecommendations! Published in 2020 at "PharmaNutrition"
DOI: 10.1016/j.phanu.2020.100219
Abstract: Abstract Background Probiotics have gained exponential attention worldwide because they are used as a therapeutic tool for management, prevention and treatment of diseases like cancer. Here, antiproliferation, anti-angiogenesis and antitumor effects of Lactobacillus acidophilus (LA)… read more here.
Keywords: cancer; antiproliferation anti; lactobacillus acidophilus; anti angiogenesis ... See more keywords
Relieving immunosuppression during long-term anti-angiogenesis therapy using photodynamic therapy and oxygen delivery.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr02750b
Abstract: Angiogenesis is an irreplaceable therapeutic cancer target, where anti-angiogenesis are drugs that are limited by their hydrophobicity and low therapeutic effects. What is more, the long-term shutdown of tumor blood vessel density also aggravates hypoxia… read more here.
Keywords: anti angiogenesis; angiogenesis; term anti; long term ... See more keywords
A human VEGF magnetic molecularly imprinted polymer for drug-free anti-angiogenesis and photothermal therapy of tumors.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc00088e
Abstract: A magnetic molecularly imprinted polymer was developed with an epitope peptide of human VEGF as a template via an epitope blotting technique. As a drug-free agent, the nanoparticles can significantly suppress the proliferation of tumor… read more here.
Keywords: molecularly imprinted; imprinted polymer; human vegf; magnetic molecularly ... See more keywords