Anti-Angiogenic Nanomicelles For the Topical Delivery of Aflibercept to Treat Retinal Neovascular Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202108360
Abstract: The traditional intravitreal injection delivery of anti-vascular endothelial growth factor (anti-VEGF) to the posterior segment of the eye for treatment of retinal diseases is invasive and associated with sight-threatening complications. To avoid such complications, there… read more here.
Keywords: anti vegf; nanomicelles topical; delivery; anti angiogenic ... See more keywords
Supramolecular Polymer-Nanomedicine Hydrogel Loaded with Tumor Associated Macrophage-Reprogramming polyTLR7/8a Nanoregulator for Enhanced Anti-Angiogenesis Therapy of Orthotopic Hepatocellular Carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300637
Abstract: Anti-angiogenic therapies targeting inhibition of vascular endothelial growth factor (VEGF) pathway show clinical benefit in hypervascular hepatocellular carcinoma (HCC) tumors. However, HCC expresses massive pro-angiogenic factors in the tumor microenvironment (TME) in response to anti-angiogenic… read more here.
Keywords: hepatocellular carcinoma; hydrogel; anti angiogenic; therapy ... See more keywords
Tumours modulate the systemic vascular response to anti‐angiogenic therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4301
Abstract: Toxicologic evaluation of new drug candidates routinely utilizes healthy animals. In oncology, there remains a limited understanding of the effects of novel test candidates in a diseased host. For vascular modulating agents (VMAs), an increased… read more here.
Keywords: tumour host; growth; modulate systemic; anti angiogenic ... See more keywords
Combined VEGF and PDGF inhibition for neovascular AMD: anti-angiogenic properties of axitinib on human endothelial cells and pericytes in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Graefe's Archive for Clinical and Experimental Ophthalmology"
DOI: 10.1007/s00417-017-3595-z
Abstract: PurposeDrugs currently approved for neovascular age-related macular degeneration (nAMD) offer anti-VEGF monotherapy only. Platelet-derived growth factor (PDGF) signaling is pivotal to pericyte-induced stabilization of choroidal neovascularizations (CNV), and causes partial anti-VEGF resistance. No combination therapy… read more here.
Keywords: angiogenic properties; vegf pdgf; endothelial cells; properties axitinib ... See more keywords
Revival of anti-angiogenic therapies in cancer—news on an old therapeutic concept
Sign Up to like & getrecommendations! Published in 2017 at "memo - Magazine of European Medical Oncology"
DOI: 10.1007/s12254-017-0363-z
Abstract: Inhibition of angiogenesis became clinical reality in 2004 with the approval of bevacizumab in metastatic colorectal cancer and we are now approaching the expiration dates of the patents for bevacizumab in the US in July… read more here.
Keywords: concept; angiogenic therapies; cancer entities; cancer ... See more keywords
Anti-angiogenesis revisited: reshaping the treatment landscape of advanced non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of pharmacal research"
DOI: 10.1007/s12272-022-01382-6
Abstract: Although anti-angiogenic agents have been of limited use in the treatment of non-small cell lung cancer (NSCLC) until recently, further roles for the use of angiogenesis inhibition have emerged in the era of targeted therapy… read more here.
Keywords: therapy; anti angiogenic; treatment; tumor ... See more keywords
Combination of metronomic administration and target delivery strategies to improve the anti-angiogenic and anti-tumor effects of triptolide
Sign Up to like & getrecommendations! Published in 2019 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-019-00665-8
Abstract: The metronomic administration of a low-dose cytotoxic agent with no prolonged drug-free breaks is an anti-angiogenic cancer treatment method. The use of nano-formulations in this manner enhances anti-tumor efficacy and reduces toxicity by inhibiting angiogenic… read more here.
Keywords: metronomic administration; administration; delivery; anti tumor ... See more keywords
Anti-Angiogenic Tyrosine Kinase Inhibitors and Reversible Posterior Leukoencephalopathy Syndrome: Could Hypomagnesaemia Be the Trigger?
Sign Up to like & getrecommendations! Published in 2017 at "Drug Safety"
DOI: 10.1007/s40264-017-0508-3
Abstract: Reversible posterior leukoencephalopathy syndrome (RPLS), also known frequently as posterior reversible encephalopathy syndrome (PRES), is a characteristic acute neuro-radiology syndrome with clinical presentation that typically includes acute hypertension, seizures and other neurological symptoms and signs.… read more here.
Keywords: anti angiogenic; leukoencephalopathy syndrome; rpls; posterior leukoencephalopathy ... See more keywords
Synthetic anti-angiogenic genomic therapeutics for treatment of neovascular age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2021 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2021.04.001
Abstract: Abstract In light of the intriguing potential of anti-angiogenic approach in suppressing choroidal neo-vascularization, we attempted to elaborate synthetic gene delivery systems encapsulating anti-angiogenic plasmid DNA as alternatives of clinical antibody-based therapeutics. Herein, block copolymer… read more here.
Keywords: dna; choroidal neo; treatment; anti ... See more keywords
Acetyl-l-carnitine is an anti-angiogenic agent targeting the VEGFR2 and CXCR4 pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.04.018
Abstract: Carnitines play an important role in the energy exchange in cells, and are involved in the transport of fatty acids across the inner mitochondrial membrane. l-Acetylcarnitine (ALCAR) is an acetic acid ester of carnitine that… read more here.
Keywords: acetyl carnitine; anti; alcar; cancer ... See more keywords
Towards anti-angiogenic activity of NiFe2O4 nanoparticles
Sign Up to like & getrecommendations! Published in 2021 at "Ceramics International"
DOI: 10.1016/j.ceramint.2021.02.191
Abstract: Abstract In this study, NiFe2O4 nanoparticles (NPs) were prepared using the polymeric precursor method and calcined at 500°C for 4 hours with (S- NiFe2O4) and without (NiFe2O4) CTAB as a surfactant, respectively. The magnetic and… read more here.
Keywords: nife2o4; angiogenic activity; nife2o4 nanoparticles; anti angiogenic ... See more keywords