Anti‐PD‐1 antibodies in metastatic uveal melanoma: a treatment option?
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Medicine"
DOI: 10.1002/cam4.887
Abstract: Uveal melanomas (UMs) are a rare form of cancer with clinical and pathological characteristics distinct from cutaneous melanomas. Ipilimumab has shown efficacy and safety in the treatment of metastatic UM. This provides a rationale for… read more here.
Keywords: antibodies metastatic; treatment; disease; tumor assessment ... See more keywords
Combining anti-PD-1 antibodies with Mn2+-drug coordinated multifunctional nanoparticles for enhanced cancer therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120897
Abstract: Immune checkpoint blockade therapy, particularly the use of engineered monoclonal antibodies against programmed cell death protein 1 (α-PD1) for activating T cells to kill cancer cells, becomes an effective strategy for cancer treatment. Despite its… read more here.
Keywords: core shell; drug; anti antibodies; cancer ... See more keywords
Refractory epilepsy associated with anti-ribosomal P antibodies successfully treated with topiramate
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2020.577144
Abstract: We report the case of a 25-year-old woman who developed temporal lobe epilepsy associated with systemic lupus erythematosus (SLE). Serum and cerebrospinal fluid samples showed high titers of anti-ribosomal P (anti-P) antibodies with negative anti-NMDAR… read more here.
Keywords: epilepsy; anti ribosomal; refractory epilepsy; associated anti ... See more keywords
90Y-Labeled Gold Nanoparticle Depot (NPD) Combined with Anti-PD-L1 Antibodies Strongly Inhibits the Growth of 4T1 Tumors in Immunocompetent Mice and Induces an Abscopal Effect on a Distant Non-Irradiated Tumor.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00572
Abstract: The effectiveness and normal tissue toxicity of a novel nanoparticle depot (NPD) brachytherapy seed incorporating gold nanoparticles (AuNPs) labeled with β-particle emitting, 90Y (termed a "radiation nanomedicine"), were studied for the treatment of 4T1 triple-negative… read more here.
Keywords: npd incorporating; tumor; primary tumor; growth ... See more keywords
Bi-valent polysaccharides of Vi capsular and O9 O-antigen in attenuated Salmonella Typhimurium induce strong immune responses against these two antigens
Sign Up to like & getrecommendations! Published in 2017 at "NPJ Vaccines"
DOI: 10.1038/s41541-017-0041-5
Abstract: Salmonella Typhi is the causative agent of typhoid fever in humans, responsible for approximately 21 million infections and 222,000 deaths globally each year. The current licensed vaccines provide moderate protection to recipients aged >2 years.… read more here.
Keywords: typhoid fever; salmonella; typhimurium; antigen ... See more keywords
Antibody response after two doses of the SARS-CoV-2 Comirnaty vaccine in a Covid-19 positive and Covid-19 negative Italian healthcare workers cohort
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Clinical and Laboratory Investigation"
DOI: 10.1080/00365513.2022.2034036
Abstract: Abstract Background Extensive vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is now universally regarded as one of the most effective strategies for counteracting the current pandemic. The durability of the immune response of… read more here.
Keywords: response; covid; comirnaty vaccine; anti antibodies ... See more keywords
Axial muscle weakness and the rimmed vacuoles in muscle histology in inflammatory myopathy with anti-ku antibody: a case report
Sign Up to like & getrecommendations! Published in 2021 at "Scandinavian Journal of Rheumatology"
DOI: 10.1080/03009742.2021.1894825
Abstract: A 41-year-old male Chinese patient had an incidental finding of elevated serum creatine kinase (4000 U/L, normal range 2–200 U/L) during a routine physical examination 3 years ago, which fluctuated between 300 and 400 U/L… read more here.
Keywords: muscle; anti antibodies; histology; antibody ... See more keywords
An affinity threshold for maximum efficacy in anti-PD-1 immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2088454
Abstract: ABSTRACT Monoclonal antibodies targeting the programmed cell death protein 1 (PD-1) remain the most prevalent cancer immunotherapy both as a monotherapy and in combination with additional therapies. Despite the extensive success of anti-PD-1 monoclonal antibodies… read more here.
Keywords: anti immunotherapy; immunotherapy; affinity; maximum efficacy ... See more keywords
Excess weight and efficacy of anti-PD-1 antibodies in advanced cancer patients
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Oncology"
DOI: 10.1093/annonc/mdz253.112
Abstract: Abstract Background Immunotherapy is a new and effective form of therapy in several types of cancer, although molecular predictors of response are limited. Recently, we have described that immune-related adverse-events (irAEs) are significantly associated with… read more here.
Keywords: antibodies advanced; efficacy; excess weight; cancer ... See more keywords
High sensitivity troponin T in infants exposed to anti-Ro antibodies.
Sign Up to like & getrecommendations! Published in 2023 at "Rheumatology"
DOI: 10.1093/rheumatology/kead105
Abstract: OBJECTIVES Cardiac involvement in neonatal lupus (NLE) can present as myocarditis/endocardial fibroelastosis (EFE). It is unknown if high sensitivity troponin T (hs-cTnT) is useful in identifying subclinical myocardial inflammation in infants exposed prenatally to anti-Ro… read more here.
Keywords: infants exposed; ctnt; cardiac nle; high sensitivity ... See more keywords
Anti‐αLβ2 antibodies reveal novel endocytotic cross‐modulatory functionality
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.14996
Abstract: Antibodies targeting cell surface receptors are considered to enable highly selective therapeutic interventions for immune disorders and cancer. Their biological profiles are found, generally, to represent the net effects of antibody–target interactions. The former therapeutic… read more here.
Keywords: cross modulatory; novel endocytotic; antibodies reveal; reveal novel ... See more keywords