Occult Breast Cancer With Anti-Ri Antibody Positivity and Pontine Hot Cross Bun Sign.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.4663
Abstract: This case report describes a 40-year-old woman with occult breast cancer with anti-Ri antibody positivity and pontine hot cross bun sign. read more here.
Keywords: positivity pontine; antibody positivity; occult breast; breast cancer ... See more keywords
Association of immune-related pneumonitis with the presence of preexisting interstitial lung disease in patients with non-small lung cancer receiving anti-programmed cell death 1 antibody
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02431-8
Abstract: The safety of anti-programmed cell death 1 (PD-1) antibody for patients with preexisting interstitial lung disease (ILD) remains unknown. The aim of this study was to evaluate the dependence of preexisting ILD on anti-PD-1 antibody-induced… read more here.
Keywords: preexisting ild; anti antibody; antibody; patients preexisting ... See more keywords
Anti-PD-1 antibody-mediated activation of type 17 T-cells undermines checkpoint blockade therapy
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02795-2
Abstract: Tumors that develop in the genetic LSL-K-ras G12D murine lung cancer model are resistant to anti-PD-1 antibody treatment. Analysis of tumor-bearing lungs from anti-PD-1-treated mice revealed an up to 2.5-fold increase in IL-17-producing T-cells, with… read more here.
Keywords: checkpoint blockade; anti antibody; activation; therapy ... See more keywords
Expression, Purification, and Evaluation of Anti-IL-2Rα Antibody Secreted by Leishmania tarentolae
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-020-10088-6
Abstract: Producing a functional anti-IL-2R α antibody in Leishmania tarentolae , a trypanosomatid protozoan non-pathogenic to human, is a cost-effective and safe alternative for the production of therapeutic recombinant proteins. Expression cassettes encoding heavy and light… read more here.
Keywords: leishmania tarentolae; anti antibody; purification evaluation; antibody ... See more keywords
Anti-tumor effects of anti-PD-1 antibody, pembrolizumab, in humanized NSG PDX mice xenografted with dedifferentiated liposarcoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.02.042
Abstract: The efficacy of an immune checkpoint blockade has been demonstrated against various types of cancer, but its suitability has not been fully proven for therapies specifically targeting sarcoma. We conducted a pan-cancer tumor data analysis… read more here.
Keywords: anti antibody; mice xenografted; xenografted dedifferentiated; tumor effects ... See more keywords
Diffuse granulomatous panniculitis associated with anti PD-1 antibody therapy
Sign Up to like & getrecommendations! Published in 2018 at "JAAD Case Reports"
DOI: 10.1016/j.jdcr.2017.06.014
Abstract: Melanoma is one of the deadliest type of skin cancer, with a dismal 5-year survival rate for patients with metastatic melanoma. However, in the last decade, the development of novel immune therapy and targeted therapy… read more here.
Keywords: melanoma; anti antibody; granulomatous panniculitis; antibody ... See more keywords
Combined Radiotherapy and Anti–PD‐L1 Antibody Synergistically Enhances Antitumor Effect in Non–Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2017.04.014
Abstract: Introduction: Immune escape frequently occurs and restricts the durability of the antitumor immune response to radiotherapy. Programmed death 1 (PD‐1) and programmed death ligand 1 (PD‐L1) are important immune checkpoint molecules that could cause tumor… read more here.
Keywords: anti antibody; radiotherapy; effect; expression ... See more keywords
Anti-PL-7 antibody-positive dermatomyositis with progressive interstitial pneumonia complicated with tracheal ulcer
Sign Up to like & getrecommendations! Published in 2021 at "Respiratory Medicine Case Reports"
DOI: 10.1016/j.rmcr.2021.101449
Abstract: Tracheobronchial lesions are rare extramuscular complications for idiopathic inflammatory myopathies including dermatomyositis. We herein report a 65-year-old woman with tracheal ulcer during the progression of dermatomyositis-associated interstitial lung disease. Treatment with corticosteroids combined with immunosuppressive… read more here.
Keywords: anti antibody; antibody positive; dermatomyositis; interstitial pneumonia ... See more keywords
Preclinical Study of a Fully Human Anti-PD-L1 Antibody as a Theranostic Agent for Cancer Immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b00371
Abstract: Recently, inhibiting the PD-1/PD-L1 checkpoint pathway utilizing anti-PD-1 or anti-PD-L1 antibodies has achieved great clinical success in cancer treatment. However, anti-PD-1 immunotherapy cannot be applied to all cancer patients, no more than 25% showed a… read more here.
Keywords: anti antibody; immunotherapy; fully human; expression ... See more keywords
Doxorubicin and Anti-PD-L1 Antibody Conjugated Gold Nanoparticles for Colorectal Cancer Photochemotherapy.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.8b01157
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide. The prognosis and overall survival of CRC are known to be significantly correlated with the overexpression of PD-L1. Since combination therapies can significantly improve therapeutic… read more here.
Keywords: anti antibody; gold nanoparticles; colorectal cancer; aunp dox ... See more keywords
Bioengineered Platelets Combining Chemotherapy and Immunotherapy for Postsurgical Melanoma Treatment: Internal Core-Loaded Doxorubicin and External Surface-Anchored Anti-PD-L1 Antibody Backpacks.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c00907
Abstract: The pivotal factors affecting the survival rate of patients include metastasis and tumor recurrence after the resection of the primary tumor. Anti-PD-L1 antibody (aPD-L1) has promising efficacy but with some side effects for the off-target… read more here.
Keywords: tumor; loaded doxorubicin; treatment; bioengineered platelets ... See more keywords