Selective Covalent Targeting of Anti‐apoptotic BFL‐1 by a Sulfonium‐Tethered Peptide
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DOI: 10.1002/cbic.202000473
Abstract: Anti‐apoptotic B cell lymphoma 2 (BCL‐2) family proteins are proven targets for human cancers. Targeting the BH3‐binding pockets of these anti‐apoptotic proteins could reactivate apoptosis in BCL‐2‐depedent cancers. BFL‐1 is a BCL‐2 family protein overexpressed… read more here.
Keywords: sulfonium tethered; tethered peptide; bfl; anti apoptotic ... See more keywords
Anti‐apoptotic effect of vinpocetine on cisplatin‐induced hepatotoxicity in mice: The role of Annexin‐V, Caspase‐3, and Bax
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DOI: 10.1002/jbt.22555
Abstract: Hepatic damage is one of the most common complications related to cisplatin (Cis) use. Recently, liver protection lines are being discovered to avoid hepatic cell death as a result of oxidative, inflammatory, and apoptotic disturbance.… read more here.
Keywords: anti apoptotic; cisplatin; effect; effect vinpocetine ... See more keywords
A20 undermines alternative NF-κB activity and expression of anti-apoptotic genes in Helicobacter pylori infection
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-022-04139-y
Abstract: A hallmark of infection by the pathogen Helicobacter pylori, which colonizes the human gastric epithelium, is the simultaneous activation of the classical and alternative nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathways, underlying inflammation… read more here.
Keywords: alternative activity; apoptotic genes; helicobacter pylori; infection ... See more keywords
Sitagliptin exerts anti-apoptotic effect in nephrotoxicity induced by cisplatin in rats
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1367-2
Abstract: Sitagliptin is a selective inhibitor of dipeptidylpeptidase-4 enzyme used for the management of diabetes mellitus type II. The anti-inflammatory, antioxidant, and anti-apoptotic properties of sitagliptin were documented. This study was designed to explore the effect… read more here.
Keywords: effect; induced cisplatin; nephrotoxicity induced; anti apoptotic ... See more keywords
Neuroprotective effects of icariin in neonatal hypoxia-ischemic brain damage via its anti-apoptotic property
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DOI: 10.1007/s00381-020-04690-8
Abstract: Introduction Neonatal hypoxic-ischemic brain damage (HIBD) is a brain disease that is caused by perinatal asphyxia. Icariin (ICA), which is an active component of Epimedii (a Chinese medicinal herb), has been verified to demonstrate a… read more here.
Keywords: neuroprotective effects; anti apoptotic; brain damage; brain ... See more keywords
Antioxidative and Anti-Apoptotic Roles of Silibinin in Reversing Learning and Memory Deficits in APP/PS1 Mice
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DOI: 10.1007/s11064-017-2389-3
Abstract: Silibinin has been widely used to treat liver diseases due to its antioxidant activity. However, the effects of silibinin on the central nervous system have not been thoroughly investigated. The pathological hallmarks of Alzheimer’s disease… read more here.
Keywords: anti apoptotic; ps1 mice; antioxidative anti; silibinin ... See more keywords
A BioDesign Approach to Obtain High Yields of Biosimilars by Anti-apoptotic Cell Engineering: a Case Study to Increase the Production Yield of Anti-TNF Alpha Producing Recombinant CHO Cells
Sign Up to like & getrecommendations! Published in 2017 at "Applied Biochemistry and Biotechnology"
DOI: 10.1007/s12010-017-2540-2
Abstract: Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian cells. Human mAbs for clinical applications have focused on three areas, particularly cancer, immunological disorders,… read more here.
Keywords: production; anti apoptotic; cho cells; apoptotic cell ... See more keywords
Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
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DOI: 10.1016/j.chembiol.2020.04.004
Abstract: The BCL-2 family is composed of anti- and pro-apoptotic members that respectively protect or disrupt mitochondrial integrity. Anti-apoptotic overexpression can promote oncogenesis by trapping the BCL-2 homology 3 (BH3) "killer domains" of pro-apoptotic proteins in… read more here.
Keywords: disulfide tethering; covalent molecular; identification covalent; bfl ... See more keywords
Rac1-induced ROS is implicated in the sustained activation of anti-apoptotic protein Bcl-2 in cancer cells
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DOI: 10.1016/j.freeradbiomed.2018.10.155
Abstract: The anti-apoptotic protein Bcl-2 is strongly associated with the development of therapy resistance in a host of hematopoietic and other cancers. To that end, the post-translational modification of Bcl-2, in particular its mono- or multi-site… read more here.
Keywords: rac1; anti apoptotic; cancer cells; bcl ... See more keywords
Pro- and anti-apoptotic microRNAs are differentially regulated during estivation in Xenopus laevis.
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DOI: 10.1016/j.gene.2022.146236
Abstract: Xenopus laevis, the African clawed frog, undergoes seasonal estivation to survive periods of drought when its lake-bed habitats dry up. The frog can lose ∼30 % of its total body water, leading to conditions of… read more here.
Keywords: mir; pro anti; xenopus laevis; estivation ... See more keywords
Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation.
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DOI: 10.1016/j.jmb.2018.08.004
Abstract: FGF1 and FGF2 bind to specific cell-surface tyrosine kinase receptors (FGFRs) and activate intracellular signaling that leads to proliferation, migration or differentiation of many cell types. Besides this classical mode of action, under stress conditions,… read more here.
Keywords: cell; anti apoptotic; fgf1 fgf2; translocation ... See more keywords