Anti-BlyS antibody reduces the immune reaction against enzyme and enhances the efficacy of enzyme replacement therapy in Fabry disease model mice.
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DOI: 10.1016/j.clim.2017.01.014
Abstract: Formation of antibodies against a therapeutic enzyme is an important complication during enzyme replacement therapy (ERT) for lysosomal storage diseases. Fabry disease (FD) is caused by a deficiency of alpha-galactosidase (GLA), which results in the… read more here.
Keywords: replacement therapy; anti blys; enzyme replacement; antibody ... See more keywords