Synthesis and biological evaluation of resveratrol derivatives with anti‐breast cancer activity
Sign Up to like & getrecommendations! Published in 2020 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202000044
Abstract: Resveratrol is a natural phytoestrogen produced by plants to protect themselves from injury, UV irradiation, and fungal attack. The main active structure is E‐resveratrol, which has many pharmacological activities. As the structure of resveratrol is… read more here.
Keywords: resveratrol; derivatives anti; breast cancer; resveratrol derivatives ... See more keywords
Reverse anti-breast cancer drug resistance effects by a novel two-step assembled nano-celastrol medicine.
Sign Up to like & getrecommendations! Published in 2022 at "Nanoscale"
DOI: 10.1039/d2nr02064e
Abstract: Multidrug resistance (MDR) has become one of the most intractable problems in clinics as it would cause failure in chemotherapy. In this study, we demonstrated that a nanoscale self-assembled nanomedicine, which almost consisted of a… read more here.
Keywords: anti breast; drug; reverse anti; medicine ... See more keywords
The anti-breast cancer stem cell properties of gold(i)-non-steroidal anti-inflammatory drug complexes
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc04707a
Abstract: The anti-breast cancer stem cell (CSC) properties of a series of gold(i) complexes comprising various non-steroidal anti-inflammatory drugs (NSAIDs) and triphenylphosphine 1–8 are reported. The most effective gold(i)-NSAID complex 1, containing indomethacin, exhibits greater potency… read more here.
Keywords: stem cell; cancer stem; breast; anti breast ... See more keywords
The anti-breast cancer property of physcion via oxidative stress-mediated mitochondrial apoptosis and immune response
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceutical Biology"
DOI: 10.1080/13880209.2021.1889002
Abstract: Abstract Context Physcion (Phy) exerts several pharmacological effects including anti-inflammatory, antioxidant, and antitumor properties. Objective This study investigates the cytotoxicity and its underlying mechanisms of Phy on breast cancer. Materials and methods Human breast cancer… read more here.
Keywords: phy; cancer property; anti breast; breast cancer ... See more keywords
Anti-Breast Cancer Effect of 2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione in vivo and in vitro Through MAPK Signaling Pathway [Corrigendum]
Sign Up to like & getrecommendations! Published in 2020 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s275618
Abstract: [This corrects the article DOI: 10.2147/DDDT.S237699.]. read more here.
Keywords: cancer effect; effect dodecyl; dodecyl methoxycyclohexa; methoxycyclohexa diene ... See more keywords
1,2,3-Triazole derivatives with anti-breast cancer potential.
Sign Up to like & getrecommendations! Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026622666220415225334
Abstract: Breast cancer is one of the most prevalent malignant diseases and one of the main mortality causes among women across the world. Despite advances in chemotherapy, drug resistance remains major clinical concerns, creating an urgent… read more here.
Keywords: triazole derivatives; anti breast; breast cancer; cancer potential ... See more keywords
Design, Synthesis and Anti-breast Cancer Activity of Some Novel Substituted Isoxazoles as Anti-breast Cancer Agent.
Sign Up to like & getrecommendations! Published in 2018 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520618666171129153655
Abstract: METHODS A novel series of isoxazole (S21-S30) derivatives were designed, synthesized and screened for their anticancer activity against estrogen receptor-positive MCF-7 and negative MDA-MB-435 breast cancer cell lines. The synthesized derivative has the ability to… read more here.
Keywords: design synthesis; breast cancer; cancer; activity ... See more keywords
Application of random forest based on semi-automatic parameter adjustment for optimization of anti-breast cancer drugs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.956705
Abstract: The optimization of drug properties in the process of cancer drug development is very important to save research and development time and cost. In order to make the anti-breast cancer drug candidates with good biological… read more here.
Keywords: cancer drugs; anti breast; breast cancer; random forest ... See more keywords
Anti-Breast Cancer Activity of Essential Oil: A Systematic Review
Sign Up to like & getrecommendations! Published in 2022 at "Applied Sciences"
DOI: 10.3390/app122412738
Abstract: Breast cancer is the second highest cancer-related death worldwide. The treatment for breast cancer is via chemotherapy; however, occurrences of multidrug resistance, unselective targets, and physicochemical problems suggest that chemotherapy treatment is ineffective. Therefore, there… read more here.
Keywords: anti breast; breast cancer; essential oil; cancer ... See more keywords
2-{5-[(Z,2Z)-2-Chloro-3-(4-nitrophenyl)-2-propenylidene]-4-oxo-2-thioxothiazolidin-3-yl}-3-methylbutanoic Acid as a Potential Anti-Breast Cancer Molecule
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084091
Abstract: It was established that the synthesis of hybrid molecules containing a thiazolidinone and a (2Z)-2-chloro-3-(4-nitrophenyl)prop-2-ene structural fragments is an effective approach for the design of potential anticancer agents. Given the results of the previous SAR-analysis,… read more here.
Keywords: breast; anti breast; chloro nitrophenyl; breast cancer ... See more keywords
Prediction of ADMET Properties of Anti-Breast Cancer Compounds Using Three Machine Learning Algorithms
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28052326
Abstract: In recent years, machine learning methods have been applied successfully in many fields. In this paper, three machine learning algorithms, including partial least squares-discriminant analysis (PLS-DA), adaptive boosting (AdaBoost), and light gradient boosting machine (LGBM),… read more here.
Keywords: machine; machine learning; anti breast; breast cancer ... See more keywords